Successful umbilical cord blood transplantation from an unrelated donor for a patient with Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis
| العنوان: | Successful umbilical cord blood transplantation from an unrelated donor for a patient with Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis |
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| المؤلفون: | T Sato, Yoji Sasahara, T Hayashi, S Kumaki, Hiroshi Asada, Yoshiyuki Ohashi, Ikuko Hakozaki, Shigeru Tsuchiya, T Okuyama, Masayoshi Minegishi |
| المصدر: | Bone Marrow Transplantation. 27:883-886 |
| بيانات النشر: | Springer Science and Business Media LLC, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Epstein-Barr Virus Infections, Histiocytosis, Non-Langerhans-Cell, medicine.medical_treatment, Hepatosplenomegaly, Blood Donors, Hematopoietic stem cell transplantation, Polymerase Chain Reaction, Umbilical cord, medicine, Humans, Transplantation, Hemophagocytic lymphohistiocytosis, Umbilical Cord Blood Transplantation, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, Viral Load, Fetal Blood, medicine.disease, medicine.anatomical_structure, Child, Preschool, Cord blood, DNA, Viral, Immunology, Absolute neutrophil count, Female, medicine.symptom, business |
| الوصف: | We report a case of a 5-year-old girl with EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) who underwent cord blood (CB) stem cell transplantation (CBSCT) from an unrelated donor. The patient presented with persistent high-grade fever and hepatosplenomegaly. Because the disease was refractory to immunochemotherapy according to the HLH94 protocol, she received 2.0 x 10(7) CB nucleated cells/kg body weight (BW) after conditioning with BU/CY/etoposide. No acute GVHD developed, using FK506 for prophylaxis. The neutrophil count reached >0.5 x 10(9)/l by day 21 and the platelet count reached >50 x 10(9)/l by day 84. The patient recovered well with sequelae of neurological deficits more than 10 months after receiving CBSCT, without showing evidence of HLH or chronic GVHD. Real-time PCR proved applicable for estimation of the EBV load in PBMC of the patient. We conclude that CBSCT may be indicated for some cases of refractory EBV-HLH, who have no HLA-matched siblings and are therefore dependent on unrelated marrow donors. |
| تدمد: | 1476-5365 0268-3369 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86ba2053f7867844808fb2259155398 https://doi.org/10.1038/sj.bmt.1702999 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e86ba2053f7867844808fb2259155398 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765365 02683369 |
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