Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease
| العنوان: | Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease |
|---|---|
| المؤلفون: | Seong Soo A. An, Young Ho Park, Sungmin Kang, So Young Park, Sang Eun Kim, Min Jeong Wang, Gwang Je Kim, In Kook Chun, Kuntaek Lim, Young Chul Youn, SangHak Yi, Jee Young Han, Byoung Sub Lee, SangYun Kim, Ji Sun Yu, Jae-Won Jang |
| المصدر: | Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-10 (2017) Alzheimer's Research & Therapy |
| بيانات النشر: | BMC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Pathology, Neurology, Disease, Neuropsychological Tests, Oligomer, lcsh:RC346-429, Amyloid-β protein, chemistry.chemical_compound, 0302 clinical medicine, Cerebrospinal fluid, Medicine, Aged, 80 and over, Aniline Compounds, medicine.diagnostic_test, Middle Aged, Positron emission tomography, Biomarker (medicine), Female, Alzheimer’s disease, medicine.medical_specialty, Cognitive Neuroscience, Enzyme-Linked Immunosorbent Assay, tau Proteins, Standardized uptake value, lcsh:RC321-571, 03 medical and health sciences, Alzheimer Disease, Republic of Korea, Humans, Benzothiazoles, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:Neurology. Diseases of the nervous system, Aged, Retrospective Studies, Psychiatric Status Rating Scales, Amyloid beta-Peptides, business.industry, Research, Biomarker, Peptide Fragments, Thiazoles, 030104 developmental biology, chemistry, Positron-Emission Tomography, Neurology (clinical), business, 030217 neurology & neurosurgery, Blood sampling |
| الوصف: | Background Soluble amyloid-β (Aβ) oligomers are the major toxic substances associated with the pathology of Alzheimer’s disease (AD). The ability to measure Aβ oligomer levels in the blood would provide simple and minimally invasive tools for AD diagnostics. In the present study, the recently developed Multimer Detection System (MDS) for AD, a new enzyme-linked immunosorbent assay for measuring Aβ oligomers selectively, was used to detect Aβ oligomers in the plasma of patients with AD and healthy control individuals. Methods Twenty-four patients with AD and 37 cognitively normal control individuals underwent extensive clinical evaluations as follows: blood sampling; detailed neuropsychological tests; brain magnetic resonance imaging; cerebrospinal fluid (CSF) measurement of Aβ42, phosphorylated tau protein (pTau), and total tau protein (tTau); and 11C-Pittsburgh compound B (PIB) positron emission tomography. Pearson’s correlation analyses between the estimations of Aβ oligomer levels by MDS and other conventional AD biomarkers (CSF Aβ42, pTau, and tTau, as well as PIB standardized uptake value ratio [PIB SUVR]) were conducted. ROC analyses were used to compare the diagnostic performance of each biomarker. Results The plasma levels of Aβ oligomers by MDS were higher in patients with AD than in normal control individuals, and they correlated well with conventional AD biomarkers (levels of Aβ oligomers by MDS vs. CSF Aβ42, r = −0.443; PIB SUVR, r = 0.430; CSF pTau, r = 0.530; CSF tTau, r = 0.604). The sensitivity and specificity of detecting plasma Aβ oligomers by MDS for differentiating AD from the normal controls were 78.3% and 86.5%, respectively. The AUC for plasma Aβ oligomers by MDS was 0.844, which was not significantly different from the AUC of other biomarkers (p = 0.250). Conclusions Plasma levels of Aβ oligomers could be assessed using MDS, which might be a simple, noninvasive, and accessible assay for evaluating brain amyloid deposition related to AD pathology. Electronic supplementary material The online version of this article (doi:10.1186/s13195-017-0324-0) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 1758-9193 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cab56d8329f075b1af7de506b70e41 http://link.springer.com/article/10.1186/s13195-017-0324-0 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e8cab56d8329f075b1af7de506b70e41 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17589193 |
|---|