Cancer Cell-Sticky Hydrogels to Target the Cell Membrane of Invading Glioblastomas
| العنوان: | Cancer Cell-Sticky Hydrogels to Target the Cell Membrane of Invading Glioblastomas |
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| المؤلفون: | Pilnam Kim, Junghwa Cha |
| المصدر: | ACS Applied Materials & Interfaces. 13:31371-31378 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Materials science, Cell, Motility, Extracellular matrix, Focal adhesion, Cell membrane, Cell Movement, Cell Line, Tumor, Glioma, Cell Adhesion, medicine, Humans, Neoplasm Invasiveness, General Materials Science, Sulfhydryl Compounds, Cell adhesion, Brain Neoplasms, Cell Membrane, Hydrogels, medicine.disease, medicine.anatomical_structure, Drug Design, Focal Adhesion Protein-Tyrosine Kinases, Cancer cell, Cancer research, Glioblastoma |
| الوصف: | Owing to their remarkable infiltrative traits, glioblastomas develop unclear tumor margins toward the brain, hampering the complete resection. Since the remaining invasive cells tend to have resistance to therapeutics and cause recurrence around the surgical voids, this has been a major challenge for glioblastoma treatment. Thus, we design a cancer cell-sticky hydrogel (CSH) that interacts with the glioblastoma cells to impede their invasive motility by modifying the cell membrane with active thiol-enriched interfaces. Highly reactive thiols at the cell surface can make the infiltrated cancer cells adhere to the hydrogel, resulting in increased cell adhesion and decreased motility. Cotreatment with the CSH and chemical inhibitors of the major proinvasive molecules, focal adhesion kinase and hyaluronic acid synthase, maximized the invasion-inhibitory effect. In addition, a significant decrease in tumor mass was achieved via CSH implantation in mouse models. Overall, our results highlight the use of the CSH to inhibit the aggressive invasion as a novel therapeutic strategy against glioblastoma. |
| تدمد: | 1944-8252 1944-8244 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94a2d4ea446e0739a54fcecd284d710 https://doi.org/10.1021/acsami.1c00388 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e94a2d4ea446e0739a54fcecd284d710 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 19448252 19448244 |
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