Effect of benzylpenicillin on intravenous pharmacokinetics of acyclovir in red‐eared slider turtles ( Trachemys scripta elegans )
| العنوان: | Effect of benzylpenicillin on intravenous pharmacokinetics of acyclovir in red‐eared slider turtles ( Trachemys scripta elegans ) |
|---|---|
| المؤلفون: | Orhan Corum, Orkun Atik, Duygu Durna Corum, Kamil Uney, Feray Altan, Hatice Eser Faki |
| المصدر: | Journal of Veterinary Pharmacology and Therapeutics. 43:319-324 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pharmacology, Volume of distribution, Cross-Over Studies, General Veterinary, Chemistry, Acyclovir, Penicillin G, Antiviral Agents, Benzylpenicillin, Washout period, Anti-Bacterial Agents, Turtles, Red-eared slider, Trachemys scripta, Pharmacokinetics, Area Under Curve, Injections, Intravenous, Plasma concentration, medicine, Molecular mechanism, Animals, Drug Interactions, Half-Life, medicine.drug |
| الوصف: | The aim of this study was to determine the effect of benzylpenicillin on the pharmacokinetics of acyclovir in red-eared slider turtles (Trachemys scripta elegans). Six clinically healthy red-eared slider turtles weighing 400 and 580 g were used for the study. Acyclovir (40 mg/kg) and benzylpenicillin (30 mg/kg) were administered intravenously to turtles. In the study, the cross-pharmacokinetic design (2 x 2) with a 30-day washout period was performed in two periods. Plasma concentrations of acyclovir were assayed using the high-performance liquid chromatography with fluorescence detection. Pharmacokinetic parameters were calculated by two-compartment open pharmacokinetic model. Following the administration of acyclovir alone, elimination half-life (t(1/2)(beta)), area under the plasma concentration-time curve (AUC), total clearance (Cl-T), and volume of distribution at steady-state (V-dss) were 20.12 hr, 1,372 hr * mu g/mL, 0.03 L hr(-1) kg(-1), and 0.84 L/kg, respectively. Benzylpenicillin administration increased t(1/2)(beta), AUC, and V-dss while decreased Cl-T of acyclovir. These results showed that benzylpenicillin changed the pharmacokinetics of acyclovir following simultaneous administration in turtles. However, further research is needed to determine molecular mechanism of interaction in turtle. |
| تدمد: | 1365-2885 0140-7783 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a699dc7ecbd3be327025857a6a429a https://doi.org/10.1111/jvp.12860 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e9a699dc7ecbd3be327025857a6a429a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652885 01407783 |
|---|