Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress:from mouse to man
| العنوان: | Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress:from mouse to man |
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| المؤلفون: | I. Torres Aleman, Brenda W.J.H. Penninx, André Aleman, Mariska Bot, Andrea Santi |
| المساهمون: | Clinical Neuropsychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Perceptual and Cognitive Neuroscience (PCN), Clinical Cognitive Neuropsychiatry Research Program (CCNP), APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatry, APH - Digital Health |
| المصدر: | Santi, A, Bot, M, Aleman, A, Penninx, B W J H & Aleman, I T 2018, ' Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress : from mouse to man ', Translational Psychiatry, vol. 8, no. 1, 142 . https://doi.org/10.1038/s41398-018-0196-5 Translational Psychiatry, 8:142. Nature Publishing Group Translational Psychiatry Translational Psychiatry, 8(1):142. Nature Publishing Group Translational Psychiatry, Vol 8, Iss 1, Pp 1-11 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, DISORDER, SERUM IGF1, medicine.medical_treatment, Anxiety, Dexamethasone, Stress Disorders, Post-Traumatic, Mice, Insulin-like growth factor, 0302 clinical medicine, Glucocorticoid receptor, Homeostasis, Insulin-Like Growth Factor I, GENE-EXPRESSION, education.field_of_study, ASSOCIATION, Middle Aged, IGF-I, Psychiatry and Mental health, FKBP5, Female, medicine.symptom, Adult, medicine.medical_specialty, Traumatic brain injury, Population, TRAUMATIC BRAIN-INJURY, PERIPHERAL-BLOOD, Article, lcsh:RC321-571, Tacrolimus Binding Proteins, 03 medical and health sciences, Cellular and Molecular Neuroscience, HORMONE, Internal medicine, medicine, Animals, Humans, Rats, Wistar, education, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biological Psychiatry, business.industry, medicine.disease, Rats, Mice, Inbred C57BL, Affect, 030104 developmental biology, Endocrinology, Anxiogenic, BRITISH BIRTH COHORT, business, Biomarkers, Stress, Psychological, 030217 neurology & neurosurgery, Hormone |
| الوصف: | Individual susceptibility to anxiety disorders after maladaptive responses to stress is not well understood. We now report that while exploring stress responses in mice after traumatic brain injury (TBI), a condition associated to stress susceptibility, we observed that the anxiogenic effects of either TBI or exposure to life-threatening experiences (predator) were blocked when both stressors were combined. Because TBI increases the entrance into the brain of serum insulin-like growth factor I (IGF-I), a known modulator of anxiety with a wide range of concentrations in the human population, we then determined whether circulating IGF-I is related to anxiety measures. In mice, anxiety-like responses to predator were inversely related to circulating IGF-I levels. Other indicators of mood regulation such as sensitivity to dexamethasone suppression and expression levels of blood and brain FK506 binding protein 5 (FKBP5), a co-chaperone of the glucocorticoid receptor that regulates its activity, were also associated to circulating IGF-I. Indeed, brain FKBP5 expression in mice was stimulated by IGF-I. In addition, we observed in a large human cohort (n = 2686) a significant relationship between plasma IGF-I and exposure to recent stressful life events, while FKBP5 expression in blood cells was significantly associated to plasma IGF-I levels. Collectively, these data indicate that circulating IGF-I appears to be involved in mood homeostasis across different species. Furthermore, the data in mice allow us to indicate that IGF-I may be acting at least in part by modulating FKBP5 expression. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2158-3188 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b91808c7344dc94464c3e765fdf9f8 https://research.vumc.nl/en/publications/f51afc5c-7189-4cf7-9d9f-aebae656fd38 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e9b91808c7344dc94464c3e765fdf9f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21583188 |
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