Whole genome sequence revealed the fine transmission map of carbapenem-resistant Klebsiella pneumonia isolates within a nosocomial outbreak
| العنوان: | Whole genome sequence revealed the fine transmission map of carbapenem-resistant Klebsiella pneumonia isolates within a nosocomial outbreak |
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| المؤلفون: | Pengcheng Du, Sui Wj, Hongyu Ren, Lijun Wang, Jing Hou, Haijian Zhou, Mei Wang, Chen Chen, Xinxin Lu, Tian Qin, Yanfei Huang |
| المصدر: | Antimicrobial Resistance and Infection Control, Vol 7, Iss 1, Pp 1-11 (2018) Antimicrobial Resistance and Infection Control |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Klebsiella pneumoniae, Drug resistance, Disease Outbreaks, law.invention, K. pneumoniae, Medical microbiology, law, Drug Resistance, Multiple, Bacterial, Epidemiology, Medicine, Pharmacology (medical), Cross Infection, biology, Carbapenemases, Anti-Bacterial Agents, Electrophoresis, Gel, Pulsed-Field, Infectious Diseases, Transmission (mechanics), Microbiology (medical), China, medicine.medical_specialty, Critical Care, 030106 microbiology, Microbial Sensitivity Tests, beta-Lactamases, KPC-2, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Bacterial Proteins, Humans, lcsh:RC109-216, Gene, Retrospective Studies, Whole genome sequencing, business.industry, Research, Public Health, Environmental and Occupational Health, Outbreak, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, bacterial infections and mycoses, Virology, Klebsiella Infections, Carbapenem-Resistant Enterobacteriaceae, Carbapenems, business, Genome, Bacterial, Multilocus Sequence Typing |
| الوصف: | Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major cause of nosocomial infections worldwide. The transmission route of CRKP isolates within an outbreak is rarely described. This study aimed to reveal the molecular characteristics and transmission route of CRKP isolates within an outbreak of nosocomial infection. Methods Collecting case information, active screening and targeted environmental monitoring were carried out. The antibiotic susceptibility, drug-resistant genes, molecular subtype and whole genome sequence of CRKP strains were analyzed. Results Between October and December 2011, 26 CRKP isolates were collected from eight patients in a surgical intensive care unit and subsequent transfer wards of Beijing Tongren hospital, China. All 26 isolates harbored bla KPC-2, bla SHV-1, and bla CTX-M-15 genes, had the same or similar pulsed-field gel electrophoresis patterns, and belonged to the sequence type 11 (ST11) clone. By comprehensive consideration of genomic and epidemiological information, a putative transmission map was constructed, including identifying one case as an independent event distinct from the other seven cases, and revealing two transmissions starting from the same case. Conclusions This study provided the first report confirming an outbreak caused by K. pneumoniae ST11 clone co-harboring the bla KPC-2, bla CTX-M-15, and bla SHV-1 genes, and suggested that comprehensive consideration of genomic and epidemiological data can yield a fine transmission map of an outbreak and facilitate the control of nosocomial transmission. |
| اللغة: | English |
| تدمد: | 2047-2994 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c0ca8c9e6430d8e32d93b5440dc40f http://link.springer.com/article/10.1186/s13756-018-0363-8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e9c0ca8c9e6430d8e32d93b5440dc40f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20472994 |
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