Infarct Core Reliability by CT Perfusion is a Time‐Dependent Phenomenon
| العنوان: | Infarct Core Reliability by CT Perfusion is a Time‐Dependent Phenomenon |
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| المؤلفون: | Sprecher Elliot, Sivan-Hoffmann Rotem, Srour Firas, Telman Gregory, Saban Mor, Buxbaum Chen, Abergel Eitan, Eran Ayelet |
| المصدر: | Journal of Neuroimaging. 30:240-245 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Perfusion Imaging, Perfusion scanning, Logistic regression, Sensitivity and Specificity, Brain Ischemia, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Medicine, heterocyclic compounds, Radiology, Nuclear Medicine and imaging, Infarct core, cardiovascular diseases, Endovascular treatment, Aged, Aged, 80 and over, Core (anatomy), business.industry, Philips healthcare, Reproducibility of Results, Middle Aged, Stroke, Cerebral blood flow, Cardiology, Female, Neurology (clinical), Extended time, Tomography, X-Ray Computed, business, 030217 neurology & neurosurgery |
| الوصف: | Background and purpose In the setting of an extended time window for endovascular treatment (EVT) for acute stroke patients, computed tomography perfusion (CTP) has become a major tool in patient selection. However, there are some data suggesting that the initial ischemic core may be overestimated by CTP depending on stroke onset time. This study aims to evaluate possible predictors of overestimation of infarct core by CTP. Methods We studied all consecutive stroke patients undergoing EVT during 1 year who underwent CTP at admission and had a successful recanalization. Admission infarct core was measured on cerebral blood volume maps generated using the Intellispace Portal (Philips Healthcare, Best, the Netherlands) and final infarct was measured on noncontrast follow-up computed tomography at 24 hours. We defined overestimation of the infarct core as initial core minus final infarct >10 mL. Results Out of 107 patients undergoing EVT in the study period, 60 were anterior circulation and had CTP done at our institute, and of them 31 were compatible with the inclusion criteria (known time of onset, no hemorrhagic conversion, and good recanalization). Median National Institute of Health Stroke Scale on admission was 13. Median time from symptoms to CTP was 148 minutes. Seventeen patients were found to have overestimation of the infarct core. Logistic regression analyses showed time from symptom onset to CTP to be inversely related to overestimation with a cutoff of 170 minutes (sensitivity 94% and specificity 43%). Conclusion Over estimation of the infarct core by CTP in patients undergoing EVT is time dependent and so CTP results among early arrivers should be interpreted cautiously. |
| تدمد: | 1552-6569 1051-2284 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0e8b3046d0af12d7e636371e442957 https://doi.org/10.1111/jon.12692 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ea0e8b3046d0af12d7e636371e442957 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15526569 10512284 |
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