Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type
| العنوان: | Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type |
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| المؤلفون: | Bjarne Bogen, Laurence Ardouin, Thien-Phong Vu Manh, Samira Tamoutounour, Hiroaki Azukizawa, Hervé Luche, Even Fossum, Martin Guilliams, Marc Dalod, Bernard Malissen, Karine Crozat, Sandrine Henri |
| المساهمون: | Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Center for Immune Regulation [Oslo] (CIR), Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Rigshospitalet [Copenhagen], Copenhagen University Hospital-Copenhagen University Hospital, Osaka University, Course of integrated medicine, Department of Dermatology, Lehrstuhl für Regelungstechnik [Erlangen], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Journal of Immunology Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2011, 187 (9), pp.4411-5. ⟨10.4049/jimmunol.1101717⟩ Journal of Immunology, 2011, 187 (9), pp.4411-5. ⟨10.4049/jimmunol.1101717⟩ |
| بيانات النشر: | The American Association of Immunologists, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Transcription, Genetic, MESH: Receptors, G-Protein-Coupled, MESH: Genetic Markers, Receptors, G-Protein-Coupled, Mice, 0302 clinical medicine, Cell Movement, MESH: DNA Fingerprinting, Immunology and Allergy, MESH: Animals, Receptor, MESH: Antigens, CD, MESH: Cell Movement, 0303 health sciences, MESH: Dendritic Cells, biology, hemic and immune systems, Cell biology, medicine.anatomical_structure, Lymphatic system, Integrin alpha M, [SDV.IMM]Life Sciences [q-bio]/Immunology, Receptors, Chemokine, Integrin alpha Chains, Genetic Markers, XCR1, Lymphoid Tissue, MESH: Mice, Transgenic, CD8 Antigens, Immunology, Mice, Transgenic, chemical and pharmacologic phenomena, Spleen, 03 medical and health sciences, Antigen, Antigens, CD, MESH: Mice, Inbred C57BL, medicine, Animals, Humans, MESH: Mice, Transcription factor, 030304 developmental biology, MESH: Humans, MESH: Transcription, Genetic, MESH: Integrin alpha Chains, Dendritic Cells, DNA Fingerprinting, Mice, Inbred C57BL, MESH: Lymphoid Tissue, biology.protein, MESH: Antigens, CD8, MESH: Receptors, Chemokine, 030215 immunology, XCL1 |
| الوصف: | Subsets of dendritic cells (DCs) have been described according to their functions and anatomical locations. Conventional DC subsets are defined by reciprocal expression of CD11b and CD8α in lymphoid tissues (LT), and of CD11b and CD103 in non-LT (NLT). Spleen CD8α+ and dermal CD103+ DCs share a high efficiency for Ag cross-presentation and a developmental dependency on specific transcription factors. However, it is not known whether all NLT-derived CD103+ DCs and LT-resident CD8α+ DCs are similar despite their different anatomical locations. XCR1 was previously described as exclusively expressed on mouse spleen CD8α+ DCs and human blood BDCA3+ DCs. In this article, we showed that LT-resident CD8α+ DCs and NLT-derived CD103+ DCs specifically express XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin. Therefore, CD8α+ DCs and CD103+ DCs belong to a common DC subset which is unequivocally identified by XCR1 expression throughout the body. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1bc4726960ebf5d5c990b08f7f4c7b https://doi.org/10.4049/jimmunol.1101717 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ea1bc4726960ebf5d5c990b08f7f4c7b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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