MYC protein expression is associated with poor prognosis in diffuse large B cell lymphoma patients treated with RCHOP chemotherapy
| العنوان: | MYC protein expression is associated with poor prognosis in diffuse large B cell lymphoma patients treated with RCHOP chemotherapy |
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| المؤلفون: | Ya-mei Chen, Min Zhou, Hongyan Wu, Rong-Fu Zhou, Yonggong Yang, Jian Ouyang, Qiguo Zhang, Xiaoyan Shao, Bing Chen, Jing Wang, Yong Xu, Xiang-shan Fan, Jingyan Xu |
| المصدر: | Tumor Biology. 35:6757-6762 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Prognostic variable, Vincristine, Adolescent, Cyclophosphamide, medicine.medical_treatment, Biology, Disease-Free Survival, Proto-Oncogene Proteins c-myc, Antibodies, Monoclonal, Murine-Derived, International Prognostic Index, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Aged, Neoplasm Staging, Aged, 80 and over, Chemotherapy, General Medicine, Middle Aged, Prognosis, medicine.disease, Lymphoma, Gene Expression Regulation, Neoplastic, Doxorubicin, Cancer research, Prednisone, Female, Rituximab, Lymphoma, Large B-Cell, Diffuse, Diffuse large B-cell lymphoma, medicine.drug |
| الوصف: | This study aims to investigate the prognostic significance of the MYC protein expression in diffuse large B cell lymphoma (DLBCL) patients treated with RCHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone). A total of 60 patients with DLBCL from 2008 to 2013 were included. Formalin-fixed, paraffin-embedded DLBCL samples were analyzed for MYC protein expression and divided into high or low MYC group. The MYC protein expression and the international prognostic variables were evaluated. The high MYC protein expression predicted a shorter 3-year estimated overall survival (OS) and progression-free survival (PFS) versus the low MYC protein expression (57 % vs. 96 %, P < 0.001 and 50 % vs. 96 %, P = 0.001, respectively). Multivariate analysis confirmed the prognostic significance of the MYC protein expression for both OS (HR, 11.862; 95 % CI, 1.462-96.218; P = 0.021) and PFS (HR, 6.073; 95 % CI, 1.082-34.085; P = 0.040). MYC protein expression with International Prognostic Index (IPI) score distinguished patients into three risk groups with different 3-year OS rates (χ (2) 23.079; P < 0.001) and distinct 3-year PFS rates (χ (2) 15.862; P < 0.001). This study suggests that the MYC protein expression is an important inferior prognostic factor for survival in patients with DLBCL treated with RCHOP. The combinative model with IPI score and MYC protein expression could stratify DLBCL patients into prognostically relevant subgroups more effectively than either the IPI or the MYC alone. |
| تدمد: | 1423-0380 1010-4283 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3fd362f17227acbe6f8935a522583d https://doi.org/10.1007/s13277-014-1907-z |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ea3fd362f17227acbe6f8935a522583d |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14230380 10104283 |
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