Ratio of Apolipoprotein A-II/B Improves Risk Prediction of Postoperative Survival After Carotid Endarterectomy
| العنوان: | Ratio of Apolipoprotein A-II/B Improves Risk Prediction of Postoperative Survival After Carotid Endarterectomy |
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| المؤلفون: | Afshin Assadian, Nikolaus Duschek, Jürgen Falkensammer, Jelena Basic, Kurt Huber, Samarth Ghai, Johann Strassegger, Tatjana Stojakovic, Hubert Scharnagl |
| المصدر: | Stroke. 46:1700-1703 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Apolipoprotein B, medicine.medical_treatment, Apolipoprotein A-II, Carotid endarterectomy, Disease-Free Survival, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, Carotid Stenosis, Prospective Studies, Prospective cohort study, Apolipoproteins B, Advanced and Specialized Nursing, Endarterectomy, Carotid, biology, business.industry, Hazard ratio, medicine.disease, Confidence interval, Surgery, Lipoproteins, LDL, Survival Rate, Stenosis, Cardiology, biology.protein, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Biomarkers, Follow-Up Studies, Lipoprotein |
| الوصف: | Background and Purpose— Even in patients with high-grade carotid stenosis, cardiovascular morbidity causes more deaths than strokes do. Despite successful low-density lipoprotein (LDL) cholesterol lowering, a significant risk of atherosclerotic cardiovascular disease remains, eventually rendering other lipid or lipoprotein ratios more efficient treatment targets. This study aimed to investigate the predictive value of the ratio of serum apolipoprotein A-II/B for overall mortality (primary outcome) of carotid surgery patients. Methods— This single-center, nonrandomized, prospective cohort study comprised 327 consecutive patients undergoing carotid endarterectomy for high-grade internal carotid artery stenosis. Baseline lipoprotein concentrations were measured, and patients were observed for the occurrence of the primary outcome until the census date (January, 2003 to January, 2012; median follow-up, 102.3 months). Results— The ratio of apolipoprotein A-II/B (hazard ratio, 0.74 per SD; confidence interval, 0.60–0.91; P =0.004) showed the highest association with the primary outcome compared with other lipid-risk parameters, significantly improving a prognostic model based on major cardiovascular risk factors, including LDL, high-density lipoprotein, and triglycerides in terms of overall performance, calibration, and discrimination. This led to a significantly improved reclassification of 8.9% of all patients (net reclassification improvement, 0.137; P =0.006 and integrated discrimination improvement, 0.041; P P =0.030 and integrated discrimination improvement, 0.061; P =0.002). Conclusions— Apolipoprotein A-II/B significantly improves risk prediction of overall survival, also in carotid surgery patients with lower LDL levels. Consequently, this ratio might provide an efficient diagnostic tool and eventually a treatment target for actual lipid-lowering therapies, which has to be addressed in future randomized controlled trials. |
| تدمد: | 1524-4628 0039-2499 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea41e24770c16c86995106dc22a8807e https://doi.org/10.1161/strokeaha.115.009663 |
| رقم الأكسشن: | edsair.doi.dedup.....ea41e24770c16c86995106dc22a8807e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 |
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