Loneliness in Relation to Depression: The Moderating Influence of a Polymorphism of the Brain Derived Neurotrophic Factor Gene on Self-efficacy and Coping Strategies
| العنوان: | Loneliness in Relation to Depression: The Moderating Influence of a Polymorphism of the Brain Derived Neurotrophic Factor Gene on Self-efficacy and Coping Strategies |
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| المؤلفون: | Hymie Anisman, Carly Crump, Marc Bedard, Robbie Woods |
| المصدر: | Frontiers in Psychology Frontiers in Psychology, Vol 8 (2017) |
| بيانات النشر: | Frontiers Media SA, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | single nucleotide, medicine.medical_specialty, Coping (psychology), media_common.quotation_subject, lcsh:BF1-990, polymorphism, 03 medical and health sciences, 0302 clinical medicine, Genotype, medicine, Psychology, Allele, Psychiatry, General Psychology, Original Research, media_common, Brain-derived neurotrophic factor, Self-efficacy, Loneliness, 030227 psychiatry, coping, lcsh:Psychology, Feeling, brain derived neurotrophic factor, depression, medicine.symptom, self-efficacy, Neurocognitive, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | Disturbances of brain derived neurotrophic factor (BDNF) signaling, which may occur among those with a polymorphism of the Val66Met gene, comprising a Met substitution for the Val allele, may be associated with depressive cognitions. However, presumed elevated BDNF levels among individuals with the Val/Val genotype, might confer increased responsivity to contextual challenges, thus fostering vulnerability to depression. In Study 1, among undergraduate students (N = 252), increased loneliness perceptions were accompanied with depressive symptoms. This relationship was moderated by self-efficacy and BDNF genotype, such that when individuals appraised high self-efficacy, those with the Val/Val genotype, compared to Met carriers, reported greater depression scores when they perceived feeling lonely. Study 2 revealed that among undergraduate students (N = 178), lower depressive scores were associated with increased problem-focused coping among Val/Val individuals, but not Met carriers. Moreover, with increased perceived loneliness, Val/Val carriers endorsed lower problem-focused coping. Findings suggest that Val/Val individuals may have adverse neurocognitive vulnerability to loneliness experiences. |
| تدمد: | 1664-1078 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea56fa74788f48bda1b017e3e93d41ca https://doi.org/10.3389/fpsyg.2017.01224 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ea56fa74788f48bda1b017e3e93d41ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16641078 |
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