Polychlorinated biphenyls and reproductive hormones in female polar bears at Svalbard
| العنوان: | Polychlorinated biphenyls and reproductive hormones in female polar bears at Svalbard |
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| المؤلفون: | Janneche Utne Skaare, Erik Ropstad, Andrew E. Derocher, Ellen Dahl, Øystein Wiig, Elisabeth Lie, Bjørn Munro Jenssen, Marte Haave |
| المصدر: | Environmental Health Perspectives |
| بيانات النشر: | Environmental Health Perspectives, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | medicine.medical_specialty, Offspring, Health Status, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Population, Zoology, Endocrine System, Biology, chemistry.chemical_compound, Internal medicine, medicine, Animals, education, Progesterone, media_common, education.field_of_study, Dose-Response Relationship, Drug, Estradiol, Arctic Regions, Norway, Reproduction, Reproductive hormones, Public Health, Environmental and Occupational Health, Polychlorinated biphenyl, Environmental Exposure, Environmental exposure, Polychlorinated Biphenyls, Endocrinology, chemistry, Plasma concentration, Polar, Environmental Pollutants, Female, Ursidae, Research Article |
| الوصف: | High concentrations of polychlorinated biphenyls (PCBs) in polar bears from Svalbard have increased concern for that population's reproductive health. We examined whether there were associations between the plasma concentrations of PCBs and reproductive hormones [progesterone (P4)] and 17 beta-estradiol (E2)] in free-living female polar bears from Svalbard. Concentrations of P4 depended on reproductive status, and concentrations were lowest in females with offspring--females with cubs and females with yearlings. In these females, the P4 concentrations were positively correlated with plasma sigma PCBs (sum of all analyzed polychlorinated biphenyl congeners) concentrations. The sigma PCBs concentrations explained 27% of the variation in the P4 concentrations. There were no correlations between sigma PCBs and E2 and cortisol in any of the groups of polar bears, or between sigma PCBs and P4 in single polar bears. Although the sigma PCBs-P4 relationship in female polar bears with offspring is not evidence per se of a direct cause-effect association, the results indicate that PCBs may affect levels of P4 in polar bear females. There is a clear need to further assess the hormone balance and population health of polar bears at Svalbard. |
| تدمد: | 1552-9924 0091-6765 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab2990493ebce2a15e1243aa941eb1c https://doi.org/10.1289/ehp.5553 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....eab2990493ebce2a15e1243aa941eb1c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15529924 00916765 |
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