Organs-on-chips at the frontiers of drug discovery
| العنوان: | Organs-on-chips at the frontiers of drug discovery |
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| المؤلفون: | Anthony Bahinski, Eric W. Esch, Dongeun Huh |
| المصدر: | Nature Reviews Drug Discovery. 14:248-260 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Pharmacology, Drug Industry, Drug discovery, Drug Evaluation, Preclinical, General Medicine, Computational biology, Biology, Bioinformatics, Models, Biological, Organ-on-a-chip, Article, High-Throughput Screening Assays, Rare Diseases, Stratified medicine, Drug development, Drug Discovery, Animals, Humans, Computer Simulation, Pharmacokinetics, Identification (biology), Drug industry |
| الوصف: | Improving the effectiveness of preclinical predictions of human drug responses is critical to reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication and microfluidics have enabled the development of microengineered models of the functional units of human organs - known as organs-on-chips - that could provide the basis for preclinical assays with greater predictive power. Here, we examine the new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug discovery, such as target identification and validation, target-based screening, and phenotypic screening. We also discuss emerging drug discovery opportunities enabled by organs-on-chips, as well as important challenges in realizing the full potential of this technology. |
| تدمد: | 1474-1784 1474-1776 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eada92e3241c6d9fc0b4929fabc0400a https://doi.org/10.1038/nrd4539 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....eada92e3241c6d9fc0b4929fabc0400a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14741784 14741776 |
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