Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort
| العنوان: | Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort |
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| المؤلفون: | Bodil Hammer Bech, Zeyan Liew, Jørn Olsen, Ellen A. Nohr, Cathrine Carlsen Bach, Eva Cecilie Bonefeld-Jørgensen, Tine Brink Henriksen, Robert F. Asarnow, Beate Ritz, Rossana Bossi |
| المصدر: | Liew, Z, Ritz, B, Bach, C C, Asarnow, R F, Bech, B H, Nohr, E A, Bossi, R, Henriksen, T B, Bonefeld-Jørgensen, E C & Olsen, J 2018, ' Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort ', Environmental Health Perspectives, vol. 126, no. 6, pp. 067004 . https://doi.org/10.1289/EHP2754 Environmental Health Perspectives Liew, Z, Ritz, B, Bach, C C, Asarnow, R F, Bech, B H, Nohr, E A, Bossi, R, Henriksen, T B, Bonefeld-Jørgensen, E C & Olsen, J 2018, ' Prenatal exposure to perfluoroalkyl substances and IQ scores at age 5 : A study in the danish national birth cohort ', Environmental Health Perspectives, vol. 126, no. 6, 067004 . https://doi.org/10.1289/EHP2754 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Fluorocarbons/adverse effects, Health, Toxicology and Mutagenesis, Denmark, Intelligence, MEDLINE, 010501 environmental sciences, Affect (psychology), 01 natural sciences, Danish, Cohort Studies, Intelligence/drug effects, 03 medical and health sciences, Prenatal Exposure Delayed Effects/epidemiology, 0302 clinical medicine, Pregnancy, Environmental health, Environmental Pollutants/adverse effects, Medicine, Humans, 030212 general & internal medicine, Prenatal exposure, Maternal Exposure/adverse effects, 0105 earth and related environmental sciences, 2. Zero hunger, Fluorocarbons, Intelligence quotient, business.industry, Research, Public Health, Environmental and Occupational Health, Wechsler Scales, Wechsler Adult Intelligence Scale, medicine.disease, Denmark/epidemiology, language.human_language, 3. Good health, Maternal Exposure, Child, Preschool, Prenatal Exposure Delayed Effects, language, Environmental Pollutants, Female, business, Cohort study |
| الوصف: | BACKGROUND: Perfluoroalkyl substances (PFASs) are widespread persistent organic compounds that have been suggested to affect neurodevelopment.OBJECTIVE: We aimed to evaluate whether prenatal exposure to PFASs is associated with IQ in children.METHODS: We studied 1,592 pregnancies enrolled in the Danish National Birth Cohort (DNBC) during 1996-2002. Sixteen PFASs were measured in maternal plasma collected in early gestation. Child IQ was assessed at 5 y of age using the Wechsler Primary and Preschool Scales of Intelligence-Revised (WPPSI-R) administered by trained psychologists. Using multivariable linear regression models, we estimated the differences in child IQ scores according to PFAS concentration [per natural-log (ng/mL) unit increase or values categorized in quartiles].RESULTS: Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were detected in all samples, and five additional PFASs were quantified in >80% of the samples. Overall, we found no strong associations between a natural-log unit increase in each of the seven PFASs we evaluated and child IQ scores. A few positive and negative associations were found in the sex-stratified PFAS quartile analyses, but the patterns were inconsistent.CONCLUSION: Overall, we did not find consistent evidence to suggest prenatal exposure to PFASs to be associated with child IQ scores at 5 y of age in the DNBC. Some of the sex-specific observations warrant further investigation. Additional studies should examine offspring IQ at older ages and assess other functional cognitive and neuropsychiatric measures in addition to intelligence. Postnatal exposures to PFASs and mixture effects for PFASs and PFASs with other environmental pollutants should also be considered in future research. https://doi.org/10.1289/EHP2754. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1996-2002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaff64cfb3988042bf4956e0b7977deb https://pure.au.dk/portal/da/publications/prenatal-exposure-to-perfluoroalkyl-substances-and-iq-scores-at-age-5-a-study-in-the-danish-national-birth-cohort(08312051-9bd6-45aa-a589-6511cd0750f7).html |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....eaff64cfb3988042bf4956e0b7977deb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19962002 |
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