Collateral Inhibition of Transcallosal Activity Facilitates Functional Brain Asymmetry
| العنوان: | Collateral Inhibition of Transcallosal Activity Facilitates Functional Brain Asymmetry |
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| المؤلفون: | Karl Herholz, Hans Karbe, Wolf-Dieter Heiss, M. Halber |
| المصدر: | Journal of Cerebral Blood Flow & Metabolism. 18:1157-1161 |
| بيانات النشر: | SAGE Publications, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, Male, Central nervous system, Corpus callosum, Auditory cortex, Corpus Callosum, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Reference Values, medicine, Humans, Speech, Dominance, Cerebral, Temporal cortex, medicine.diagnostic_test, Brain morphometry, Brain, Neural Inhibition, Magnetic resonance imaging, Middle Aged, Magnetic Resonance Imaging, Radiography, Midbody, Glucose, medicine.anatomical_structure, Neurology, Positron emission tomography, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, Psychology, Neuroscience, 030217 neurology & neurosurgery, Tomography, Emission-Computed |
| الوصف: | The corpus callosum is the largest connection between the functionally asymmetric cerebral hemispheres. The objective of this study was to measure functional activity of callosal fiber tracts during speech processing. We analyzed the regional glucose metabolism of the corpus callosum and of speech-relevant cortical areas in 10 normal individuals at rest and during word repetition. We used three-dimensionally registered magnetic resonance imaging to visualize the individual brain morphology and high-resolution positron emission tomography for metabolic measurements. The task-induced metabolic changes of the callosal midbody and isthmus had a significant negative correlation with key regions of language processing in the left inferior frontal cortex (Brodmann's area 44) and in the right superior temporal cortex (Brodmann's area 22) (e.g., correlation of metabolic changes in the surface aspects of the right Brodmann's area 22 and the callosal midbody/isthmus: r = −0.91, P < 0.001). The study indicates that language processing in asymmetrically organized cortical areas inhibits the reciprocal transcallosal information exchange in favor of the lateralized mental operation. Our data agree with anatomic, electrophysiologic, and pharmacologic experiments that point to the important role of collateral inhibition for the transcallosal information exchange. |
| تدمد: | 1559-7016 0271-678X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2ccc8ff1d67c313a3cec25f1944428 https://doi.org/10.1097/00004647-199810000-00012 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....eb2ccc8ff1d67c313a3cec25f1944428 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15597016 0271678X |
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