Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV Infection
| العنوان: | Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV Infection |
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| المؤلفون: | Shiyuan Hou, Ziyu Liu, Ying Qikang, Xingan Wu, Wenjie Sun, Rongrong Liu, Ruixue Ma, Zhang Xiaoxiao, Yunhua Lv, Fang Wang, Xia Jin, Jiayi Shu |
| المصدر: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, 030106 microbiology, Renal Hemorrhage, Immunology, renal hemorrhage, Spleen, Pathogenesis, 03 medical and health sciences, Immunology and Allergy, Medicine, Pathological, Hantaan virus, renal tubule dilation, Original Research, Kidney, business.industry, NLRC3, virus diseases, HTNV, RC581-607, 030104 developmental biology, medicine.anatomical_structure, Knockout mouse, HFRS, Immunologic diseases. Allergy, business, Viral load |
| الوصف: | Hantaan virus (HTNV) infects humans and causes hemorrhagic fever with renal syndrome (HFRS). The development of well-characterized animal models of HFRS could accelerate the testing of vaccine candidates and therapeutic agents and provide a useful tool for studying the pathogenesis of HFRS. Because NLRC3 has multiple immunoregulatory roles, we investigated the susceptibility of Nlrc3−/− mice to HTNV infection in order to establish a new model of HFRS. Nlrc3−/− mice developed weight loss, renal hemorrhage, and tubule dilation after HTNV infection, recapitulating many clinical symptoms of human HFRS. Moreover, infected Nlrc3−/− mice showed higher viral loads in serum, spleen, and kidney than wild type C57BL/6 (WT) mice, and some of them manifested more hematological disorders and significant pathological changes within multiple organs than WT mice. Our results identify that HTNV infected Nlrc3−/− mice can develop clinical symptoms and pathological changes resembling patients with HFRS, suggesting a new model for studying the pathogenesis and testing of candidate vaccines and therapeutics. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb656627687ae20dc7456a170d2acd35 https://www.frontiersin.org/articles/10.3389/fimmu.2021.692509/full |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....eb656627687ae20dc7456a170d2acd35 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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