Circulating adipocyte fatty acid-binding protein is a predictor of cardiovascular events in patients with stable angina undergoing percutaneous coronary intervention
| العنوان: | Circulating adipocyte fatty acid-binding protein is a predictor of cardiovascular events in patients with stable angina undergoing percutaneous coronary intervention |
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| المؤلفون: | Hiroshi Ito, Tomoyuki Nishibe, Naoaki Matsuo, Toru Miyoshi, Keisuke Okawa, Masayuki Doi, Kazumasa Nosaka, Wataru Takagi, Satoshi Hirohata |
| المصدر: | BMC Cardiovascular Disorders, Vol 17, Iss 1, Pp 1-8 (2017) BMC Cardiovascular Disorders |
| بيانات النشر: | BMC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_treatment, 030204 cardiovascular system & hematology, Fatty Acid-Binding Proteins, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Postoperative Complications, Interquartile range, Predictive Value of Tests, Internal medicine, medicine, Humans, Cumulative incidence, Myocardial infarction, Angina, Stable, Prospective Studies, Aged, Retrospective Studies, Aged, 80 and over, Adipocyte, business.industry, Hazard ratio, Percutaneous coronary intervention, Middle Aged, medicine.disease, Fatty acid, 030104 developmental biology, Cardiovascular Diseases, lcsh:RC666-701, Heart failure, Conventional PCI, Cardiology, Female, lipids (amino acids, peptides, and proteins), Risk factor, Cardiology and Cardiovascular Medicine, business, Biomarkers, Follow-Up Studies, Research Article |
| الوصف: | Background Adipocyte fatty acid-binding protein (A-FABP) is expressed in both adipocytes and macrophages. Recent studies have shown that A-FABP is secreted by adipocytes and that the A-FABP concentration is associated with obesity, insulin resistance, and atherosclerosis. We have reported that the coronary atherosclerotic burden is associated with the serum A-FABP concentration. In the present study, we investigated whether the serum A-FABP concentration is associated with prognosis in patients with stable angina pectoris who have undergone percutaneous coronary intervention (PCI). Methods This was a prospective single-center trial. In total, 130 patients with stable angina pectoris undergoing their first PCI were enrolled from August 2008 to July 2010 at Kagawa Prefectural Central Hospital. The primary endpoints were cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, revascularization, and hospitalization for heart failure. Results During the follow-up (median, 50 months; interquartile range, 23–66 months), 49 cardiovascular events occurred. Kaplan–Meier analysis showed that the cumulative incidence of the primary endpoints in the high A-FABP group (median A-FABP concentration of ≥ 18.6 ng/ml) was greater than that in the low A-FABP group. Cox analysis showed that the A-FABP concentration was an independent predictor of cardiovascular events adjusted for age and the presence of multi-vessel disease (hazard ratio, 1.03; 95% confidence interval, 1.01–1.04; p = 0.01). Conclusion The serum A-FABP concentration is associated with prognosis in patients with stable angina undergoing PCI, suggesting that the serum A-FABP concentration could be useful for risk assessment of secondary prevention. Trial registration UMIN Clinical Trials Registry UMIN000029283 (registration date: September 25, 2017), retrospectively registered. |
| اللغة: | English |
| تدمد: | 1471-2261 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba86d78eff9e219fc84175a16d5024b http://link.springer.com/article/10.1186/s12872-017-0691-2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....eba86d78eff9e219fc84175a16d5024b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712261 |
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