Impact of c-erbB-2 Protein on 5-year Survival Rate of Gastric Cancer Patients after Surgery: A Cohort Study and Meta-analysis
| العنوان: | Impact of c-erbB-2 Protein on 5-year Survival Rate of Gastric Cancer Patients after Surgery: A Cohort Study and Meta-analysis |
|---|---|
| المؤلفون: | Zhenzhai Cai, He Huang, Guangrong Lu, Shu-guang Cao, Hao Wu, Yi Jiang, Weijian Sun |
| المصدر: | Tumori Journal. 103:249-254 |
| بيانات النشر: | SAGE Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, 5 year survival rate, Receptor, ErbB-2, Kaplan-Meier Estimate, Disease-Free Survival, Protein expression, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Humans, Medicine, Aged, business.industry, Cancer, Five-year survival rate, General Medicine, Middle Aged, Prognosis, medicine.disease, Surgery, Gene Expression Regulation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Meta-analysis, Immunohistochemistry, Female, 030211 gastroenterology & hepatology, C erbb 2 protein, business, Cohort study |
| الوصف: | Objective To explore the association of c-erbB-2 protein expression with clinicopathological characteristics and prognosis of gastric cancer (GC) after surgery. Methods A total of 133 patients undergoing surgical resection for GC between March 2006 and January 2009 in the Second Affiliated Hospital of Wenzhou Medical University were included in this study. c-erbB-2 protein expression was determined by immunohistochemistry. Afterwards, a meta-analysis was performed to further confirm the association between c-erbB-2 protein expression and GC by employing stringent inclusion and exclusion criteria. All data analyses were conducted with STATA 12.0 and SPSS 19.0. Results There was no significant difference in c-erbB-2 expression among patients with various parameters including age, gender and histological types (all p>0.05). Among 133 GC patients, 32 patients presented c-erbB-2-positive expression and 101 presented c-erbB-2-negative expression (24.1% vs. 75.9%). The c-erbB-2-positive expression rate was significantly higher in GC tissues of patients with lymph node metastasis than those without. Similarly, a significant increase in c-erbB-2 expression was observed in well/moderately differentiated GC tissues compared with poorly differentiated GC. Patients with negative c-erbB-2 expression had a higher 5-year survival rate than those with positive c-erbB-2 expression, which was consistent with the results of the meta-analysis (OR = 0.54, 95% CI 0.37-0.80, p = 0.002). Conclusions Our study demonstrated that high expression of c-erbB-2 protein was strongly associated with lymph node metastasis, histological differentiation and 5-year survival rate in GC patients after surgery. |
| تدمد: | 2038-2529 0300-8916 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc8e941cb4aee907433a40239da1cf9 https://doi.org/10.5301/tj.5000444 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ebc8e941cb4aee907433a40239da1cf9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20382529 03008916 |
|---|