IL-9 Exerts Antitumor Effects in Colon Cancer and Transforms the Tumor Microenvironment In Vivo
| العنوان: | IL-9 Exerts Antitumor Effects in Colon Cancer and Transforms the Tumor Microenvironment In Vivo |
|---|---|
| المؤلفون: | Yang Huang, Hua Zhao, Xinguo Zhu, Zhe Zhang, Dongbao Li, Mingbing Sun, Xiaoqiang Dong, Xin Zhao, Deli Mao, Jin Wang |
| المصدر: | Technology in Cancer Research & Treatment |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Cancer Research, Colorectal cancer, medicine.medical_treatment, Gene Expression, Inflammation, anti-tumor effect, 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, Cell Line, Tumor, medicine, cytokine, Tumor Microenvironment, Animals, Humans, Interleukin 9, Neoplasm Metastasis, 030304 developmental biology, Aged, Neoplasm Staging, Aged, 80 and over, 0303 health sciences, Tumor microenvironment, Local Immunity in the Tumor Microenvironment, business.industry, Melanoma, Growth factor, Interleukin-9, Middle Aged, medicine.disease, IL-9, Prognosis, Immunohistochemistry, Xenograft Model Antitumor Assays, Disease Models, Animal, Cytokine, Cell Transformation, Neoplastic, Oncology, colon cancer, 030220 oncology & carcinogenesis, Colonic Neoplasms, Cancer research, Original Article, Female, medicine.symptom, Neoplasm Grading, business |
| الوصف: | As a newly discovered cytokine, interleukin 9 was initially considered a T-lymphocyte growth factor. Interleukin 9 affects target cells by binding to a member of the γc-family of receptors and is involved in inflammation, autoimmune diseases, and other ailments. In recent years, mounting evidence reveals that interleukin 9 exerts antitumor effects, which has attracted considerable attention. Many previous studies were performed in vivo by establishing a mouse model of melanoma. Here, interleukin 9 protein and messenger RNA expression levels were both low in colon carcinoma tissue specimens, as assessed by immunohistochemistry and quantitative real-time polymerase chain reaction. In addition, interleukin 9 expression in these samples was correlated with TNM staging, Dukes staging, lymph node metastasis, and good prognosis, but not with gender, age, tumor size, tumor differentiation, and hepatic metastasis. In vivo, by establishing a mouse subcutaneous allograft model, we found that interleukin 9 overexpression inhibited tumor growth and resulted in longer survival time. Then, antitumor immune responses were increased by interleukin 9 as demonstrated by flow cytometry. Furthermore, interleukin 9 was shown to exert antitumor effects by regulating T-cell function and killing tumor cells in the tumor microenvironment. Overall, this study revealed that interleukin 9 exerts robust antitumor effects in colon cancer and transforms the tumor microenvironment in vivo. |
| اللغة: | English |
| تدمد: | 1533-0338 1533-0346 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcaadce5a46bd161fc5d780984bc15a http://europepmc.org/articles/PMC6598323 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ebcaadce5a46bd161fc5d780984bc15a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15330338 15330346 |
|---|