Incorporation of 5-fluorouracil into hepatoma and normal tissue RNA at protein depletion in the rat
| العنوان: | Incorporation of 5-fluorouracil into hepatoma and normal tissue RNA at protein depletion in the rat |
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| المؤلفون: | Unne Stenram, Gunnel Roos |
| المصدر: | Journal of Surgical Oncology. 65:155-158 |
| بيانات النشر: | Wiley, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | medicine.medical_specialty, Biology, chemistry.chemical_compound, Hepatic Artery, Liver Neoplasms, Experimental, Therapeutic index, Internal medicine, Casein, medicine, Animals, Infusions, Intra-Arterial, RNA, Neoplasm, Cytotoxicity, Kidney, DNA synthesis, Proteins, RNA, DNA, Neoplasm, General Medicine, Rats, medicine.anatomical_structure, Endocrinology, Liver, Oncology, chemistry, Toxicity, Surgery, Fluorouracil, DNA |
| الوصف: | Background and Objectives 5-fluorouracil (5-FU) exerts its effects mainly by its incorporation into RNA and inhibition of DNA synthesis. Its toxicity may therefore be estimated by measuring its incorporation into RNA. Protein malnutrition has been considered to increase the toxicity of 5-FU. Methods Rats with a hepatoma implanted into the liver were fed on either a 25% or a 0% casein diet for 1 week. On the last day, they were infused via the hepatic artery with a therapeutic dose of 3H-5-FU. Its incorporation into RNA was measured in hepatoma and several normal tissues. Results Protein deprivation increased the incorporation of 5-FU into liver and intestinal RNA. Incorporation into hepatoma RNA did not increase significantly, but the ratio, liver/hepatoma RNA incorporation, remained unchanged. Conclusions Protein deprivation might increase the toxicity of 5-FU on liver and intestine. J. Surg. Oncol. 1997;65:155–158. © 1997 Wiley-Liss, Inc. |
| تدمد: | 1096-9098 0022-4790 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec214094c408475907b46e04b95f9ce6 https://doi.org/10.1002/(sici)1096-9098(199707)65:3<155::aid-jso2>3.0.co;2-5 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ec214094c408475907b46e04b95f9ce6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969098 00224790 |
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