Existence of CD8α-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian species
| العنوان: | Existence of CD8α-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian species |
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| المؤلفون: | Rachel Guiton, Karine Crozat, Yannick O. Alexandre, Marc Dalod, Vanessa Contreras, Michel Bonneau, Thibault Andrieu, Thien-Phong Vu Manh, Isabelle Schwartz-Cornil, Mathieu Epardaud, Ariel Savina, Nicolas Bertho, Jayne Hope, Luc Jouneau, Céline Urien, Sebastian Amigorena |
| المساهمون: | Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Immunologie de Marseille Luminy (CIML - INSERM U631 - CNRS UMR 6102), Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Energie Atomique, Di- vision of Immuno-Virology, Direction des Sciences du Vivant, Institut des Maladies Emergentes et des The´rapies Innovantes, Fontenay-aux-Rose, Institute for Animal Health, Compton, Institut Curie, PSL Research University, INSERM U932., Unité de recherche Virologie et Immunologie Moléculaires (VIM), Institut National de la Recherche Agronomique (INRA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut des Maladies Emergentes et des Thérapies Innovantes (IMETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institute for Animal Health (IAH), Biotechnology and Biological Sciences Research Council, Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Imagerie Interventionnelle (CR2I), Unité de recherche Virologie et Immunologie Moléculaires ( VIM ), Institut National de la Recherche Agronomique ( INRA ), Centre d'Immunologie de Marseille - Luminy ( CIML ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Institut des Maladies Emergentes et des Thérapies Innovantes ( IMETI ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Institute for Animal Health ( IAH ), Immunité et cancer ( U932 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut Curie-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche en Imagerie Interventionnelle ( CR2I ), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Biotechnology and Biological Sciences Research Council (BBSRC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Curie-Université Paris Descartes - Paris 5 (UPD5) |
| المصدر: | Journal of Immunology Journal of Immunology, 2010, 185 (6), pp.3313-3325. ⟨10.4049/jimmunol.1000824⟩ Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (6), pp.3313-25. ⟨10.4049/jimmunol.1000824⟩ Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (6), pp.3313-25. 〈10.4049/jimmunol.1000824〉 Journal of Immunology, 2010, 185 (6), pp.3313-25. ⟨10.4049/jimmunol.1000824⟩ |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], Conserved sequence, Immune tolerance, Interleukin 22, Mice, 0302 clinical medicine, Immunology and Allergy, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, MESH : Female, MESH: Animals, Domestic, Cells, Cultured, Conserved Sequence, Skin, 0303 health sciences, Cultured, MESH: Conserved Sequence, MESH: Dendritic Cells, MESH : Immune Tolerance, hemic and immune systems, Phenotype, Cell biology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Lymph, MESH: Cells, Cultured, MESH: Lymph, XCR1, MESH: Immune Tolerance, Cells, CD8 Antigens, Dipeptidyl Peptidase 4, Immunology, chemical and pharmacologic phenomena, Biology, MESH : Lymph, 03 medical and health sciences, MESH: Gene Expression Profiling, MESH: Skin, Species Specificity, MESH : Conserved Sequence, MESH : Mice, MESH : Sheep, Domestic, MESH : Cells, Cultured, MESH : Skin, Immune Tolerance, MESH : Species Specificity, MESH: Species Specificity, Animals, Humans, Antigens, Gene, MESH: Mice, Sheep, Domestic, 030304 developmental biology, Sheep, MESH: Humans, MESH : Gene Expression Profiling, Gene Expression Profiling, MESH : Humans, CD8, Dendritic cell, Dendritic Cells, MESH: Dipeptidyl Peptidase 4, MESH : Dendritic Cells, MESH : Dipeptidyl Peptidase 4, MESH : Animals, MESH: Antigens, CD8, MESH: Sheep, Domestic, MESH : Antigens, CD8, MESH: Female, 030215 immunology |
| الوصف: | International audience; The mouse lymphoid organ-resident CD8alpha(+) dendritic cell (DC) subset is specialized in Ag presentation to CD8(+) T cells. Recent evidence shows that mouse nonlymphoid tissue CD103(+) DCs and human blood DC Ag 3(+) DCs share similarities with CD8alpha(+) DCs. We address here whether the organization of DC subsets is conserved across mammals in terms of gene expression signatures, phenotypic characteristics, and functional specialization, independently of the tissue of origin. We study the DC subsets that migrate from the skin in the ovine species that, like all domestic animals, belongs to the Laurasiatheria, a distinct phylogenetic clade from the supraprimates (human/mouse). We demonstrate that the minor sheep CD26(+) skin lymph DC subset shares significant transcriptomic similarities with mouse CD8alpha(+) and human blood DC Ag 3(+) DCs. This allowed the identification of a common set of phenotypic characteristics for CD8alpha-like DCs in the three mammalian species (i.e., SIRP(lo), CADM1(hi), CLEC9A(hi), CD205(hi), XCR1(hi)). Compared to CD26(-) DCs, the sheep CD26(+) DCs show 1) potent stimulation of allogeneic naive CD8(+) T cells with high selective induction of the Ifngamma and Il22 genes; 2) dominant efficacy in activating specific CD8(+) T cells against exogenous soluble Ag; and 3) selective expression of functional pathways associated with high capacity for Ag cross-presentation. Our results unravel a unifying definition of the CD8alpha(+)-like DCs across mammalian species and identify molecular candidates that could be used for the design of vaccines applying to mammals in general. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec330486711420d430b220611f8b2c5d https://pubmed.ncbi.nlm.nih.gov/20702727 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ec330486711420d430b220611f8b2c5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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