Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients
| العنوان: | Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients |
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| المؤلفون: | Tie-bang Liu, Wen-tao Lai, Min-zhi Li, Wen-feng Deng, Jie Zhao, Dan Xu, Fusheng He, Yang-hui Liu, Mingbang Wang, Yuan-yuan Guo, Han Rong, Xin-hui Xie, Ying-li Zhang, Qi-fan Yang, Shu-xian Xu, Sheng Wang, Shu-wei Ye, Ying-jia Yang |
| المصدر: | Psychological medicine. 51(1) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Gut flora, behavioral disciplines and activities, law.invention, 03 medical and health sciences, Probiotic, 0302 clinical medicine, law, mental disorders, Hamd, medicine, Humans, KEGG, Applied Psychology, Bifidobacterium, Aged, Genetics, Depressive Disorder, Major, biology, Tryptophan, Bacteroidetes, Middle Aged, medicine.disease, biology.organism_classification, Gastrointestinal Microbiome, Psychiatry and Mental health, 030104 developmental biology, Metagenomics, Major depressive disorder, Female, 030217 neurology & neurosurgery |
| الوصف: | BackgroundThe microbiota–gut–brain axis, especially the microbial tryptophan (Trp) biosynthesis and metabolism pathway (MiTBamp), may play a critical role in the pathogenesis of major depressive disorder (MDD). However, studies on the MiTBamp in MDD are lacking. The aim of the present study was to analyze the gut microbiota composition and the MiTBamp in MDD patients.MethodsWe performed shotgun metagenomic sequencing of stool samples from 26 MDD patients and 29 healthy controls (HCs). In addition to the microbiota community and the MiTBamp analyses, we also built a classification based on the Random Forests (RF) and Boruta algorithm to identify the gut microbiota as biomarkers for MDD.ResultsThe Bacteroidetes abundance was strongly reduced whereas that of Actinobacteria was significantly increased in the MDD patients compared with the abundance in the HCs. Most noteworthy, the MDD patients had increased levels of Bifidobacterium, which is commonly used as a probiotic. Four Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologies (KOs) (K01817, K11358, K01626, K01667) abundances in the MiTBamp were significantly lower in the MDD group. Furthermore, we found a negative correlation between the K01626 abundance and the HAMD scores in the MDD group. Finally, RF classification at the genus level can achieve an area under the receiver operating characteristic curve of 0.890.ConclusionsThe present findings enabled a better understanding of the changes in gut microbiota and the related Trp pathway in MDD. Alterations of the gut microbiota may have the potential as biomarkers for distinguishing MDD patients form HCs. |
| تدمد: | 1469-8978 0033-2917 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4307f626e2864c915d779139b59a58 https://pubmed.ncbi.nlm.nih.gov/31685046 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ec4307f626e2864c915d779139b59a58 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14698978 00332917 |
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