Comparison of the New Viscoelastic Coagulation Analyzer ClotPro® With ROTEM® Delta and Conventional Coagulation Tests in Critically Ill Patients With COVID-19
| العنوان: | Comparison of the New Viscoelastic Coagulation Analyzer ClotPro® With ROTEM® Delta and Conventional Coagulation Tests in Critically Ill Patients With COVID-19 |
|---|---|
| المؤلفون: | Stefan Ulbing, Johannes Gratz, Eva Schaden, Conrad Lacom, Lukas Infanger, Christoph Dibiasi, Marion Wiegele |
| المصدر: | Frontiers in Medicine Frontiers in Medicine, Vol 8 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Medicine (General), Spectrum analyzer, Coronavirus disease 2019 (COVID-19), critically ill, ClotPro®, Viscoelasticity, R5-920, Coagulation testing, Coagulopathy, Medicine, viscoelastic test, coagulation, Original Research, Critically ill, business.industry, ROTEM Delta®, COVID-19, General Medicine, medicine.disease, Thromboelastometry, Coagulation, comparison, point-of-care, business, Biomedical engineering |
| الوصف: | Background: Viscoelastic coagulation testing has been suggested to help manage coagulopathy in critically ill patients with COVID-19. However, results from different viscoelastic devices are not readily comparable. ClotPro® is a novel thromboelastometry analyzer offering a wider range of commercially available assays.Methods: We compared the results from ClotPro with results from the well-established ROTEM® Delta device and conventional coagulation tests in critically ill patients with COVID-19.Results: Viscoelastic parameters indicated the presence of a potentially hypercoagulable state in the majority of patients. In up to 95 paired measurements, we found strong correlations between several parameters routinely used in clinical practice: (i) EX test vs. EXTEM CT, A5, A10, MCF, (ii) IN test vs. INTEM A5, A10, MCF, and (iii) FIB test vs. FIBTEM A5, A10, MCF (all R > 0.7 and p < 0.001). In contrast, IN test CT vs. INTEM CT showed only a moderate correlation (R = 0.53 and p < 0.001). Clot strength parameters of both devices exhibited strong correlations with platelet counts and fibrinogen levels (all R > 0.7 and p < 0.001). Divergent correlations of intrinsically activated assays with aPTT and anti-factor Xa activity were visible. Regarding absolute differences of test results, considerable delta occurred in CT, CFT, and clot strength parameters (all p < 0.001) between both devices.Conclusions: Several parameters obtained by ClotPro show strong correlations with ROTEM Delta. Due to weak correlations of intrinsically activated clotting times and considerable absolute differences in a number of parameters, our findings underline the need for device-specific algorithms in this patient cohort. |
| اللغة: | English |
| تدمد: | 2296-858X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4cfae9e3f88d8e46a6ef1563b10c97 http://europepmc.org/articles/PMC8635118 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ec4cfae9e3f88d8e46a6ef1563b10c97 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2296858X |
|---|