Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia
| العنوان: | Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia |
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| المؤلفون: | G. A. Tolstikov, Nariman F. Salakhutdinov, V. A. Vavilin, E. M. Stakhneva, O. G. Safronova, S. I. Makarova, V. V. Lyakhovich, Yu. P. Nikitin, Yu. I. Ragino |
| المصدر: | Bulletin of Experimental Biology and Medicine. 146:206-209 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, Simvastatin, medicine.medical_specialty, Antioxidant, Endothelium, medicine.medical_treatment, Hypercholesterolemia, Nitrous Oxide, Antioxidants, General Biochemistry, Genetics and Molecular Biology, Lipid peroxidation, chemistry.chemical_compound, Von Willebrand factor, Internal medicine, von Willebrand Factor, polycyclic compounds, medicine, Animals, Fluorometry, Endothelial dysfunction, Analysis of Variance, Endothelin-1, biology, Aryldialkylphosphatase, Cholesterol, Anticholesteremic Agents, nutritional and metabolic diseases, General Medicine, Glycyrrhizic Acid, medicine.disease, Diet, Endocrinology, medicine.anatomical_structure, chemistry, biology.protein, lipids (amino acids, peptides, and proteins), Endothelium, Vascular, Rabbits, medicine.drug |
| الوصف: | Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 microg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26-58 and 21-29%, respectively, compared to 200 microg/kg simvastatin, p |
| تدمد: | 1573-8221 0007-4888 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec53ad0aed120b329ea64441f88e0927 https://doi.org/10.1007/s10517-008-0252-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ec53ad0aed120b329ea64441f88e0927 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15738221 00074888 |
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