Cognitive impairment by non‐insulin‐dependent diabetes mellitus was attenuated by dietary supplements of marble vine ( Dioclea reflexa ) and plantain ( Musa paradisiaca ) dough meals in albino rats
| العنوان: | Cognitive impairment by non‐insulin‐dependent diabetes mellitus was attenuated by dietary supplements of marble vine ( Dioclea reflexa ) and plantain ( Musa paradisiaca ) dough meals in albino rats |
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| المؤلفون: | Oluwatooyin F. Osundahunsi, Mary A. Ajatta, Olumayowa R Oladipupo, Sunday Solomon Josiah, Olufunmilayo Sade Omoba |
| المصدر: | Journal of Food Biochemistry. 45 |
| بيانات النشر: | Hindawi Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Glucose, medicine.medical_specialty, 030309 nutrition & dietetics, medicine.medical_treatment, Biophysics, medicine.disease_cause, Calcium Carbonate, Diabetes Mellitus, Experimental, 03 medical and health sciences, 0404 agricultural biotechnology, Nutraceutical, Internal medicine, Diabetes mellitus, medicine, Animals, Cognitive Dysfunction, Rats, Wistar, Meals, Plantago, Pharmacology, 0303 health sciences, Meal, Plant Extracts, business.industry, Insulin, food and beverages, Type 2 Diabetes Mellitus, Musa, 04 agricultural and veterinary sciences, Cell Biology, Streptozotocin, medicine.disease, 040401 food science, Rats, Metformin, Endocrinology, Diabetes Mellitus, Type 2, Dietary Supplements, Dioclea, business, Oxidative stress, Food Science, medicine.drug |
| الوصف: | This study investigates the protective effect of formulated marble vine/plantain dough meals on cognitive impairment in diabetic rats. Wistar rats were divided into eight groups (n = 6) and fed with HFD for 14 days and a single dose of streptozotocin intraperitoneally on the 14th day (except control rats). Diabetic rats were treated with formulated diets and metformin. The ameliorative effect of the formulated doughs on cerebral damage in diabetic rats with respect to weight gain/loss, glucose and insulin levels, oxidative damage, neurological dysfunction, and histological alterations were assessed. The formulated diet had high protein and fiber content values ranged from 13.00 to 25.04 g/100 g and from 5.23 to 6.20 g/100 g, respectively compared to the control. Blood glucose level was observed, thereby mitigating the cerebral oxidative damage. The diet significantly ameliorated the neurological dysfunction as adjudged by increased dopamine concentration and lowered acetylcholinesterase activity; results were also supported by the outcomes from brain histopathological study. PRACTICAL APPLICATIONS: Underutilized leguminous seeds such as marble vine seeds are known for their nutraceutical potentials due to their numerous biochemical components. The study provides preliminary information on the potential of marble vine/plantain functional dough meals in the management of neurological complications resulting from type 2 diabetes mellitus in albino rats. Generally, the formulated doughs possess neuroprotective potentials in preventing neurological complications arising from diabetes. However, the effect of marble vine-plantain dough meal in managing the brain damage should be further investigated through the clinical trials before development for pharmaceutical applications. |
| تدمد: | 1745-4514 0145-8884 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec694a5b6c5956c4046788fbd7a87e73 https://doi.org/10.1111/jfbc.13473 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ec694a5b6c5956c4046788fbd7a87e73 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17454514 01458884 |
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