Collective Total Synthesis of Aspidofractinine Alkaloids through the Development of a Bischler–Napieralski/Semipinacol Rearrangement Reaction
| العنوان: | Collective Total Synthesis of Aspidofractinine Alkaloids through the Development of a Bischler–Napieralski/Semipinacol Rearrangement Reaction |
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| المؤلفون: | Xiao-Ming Zhang, Tian Ke, Fu-Min Zhang, Qing-Bo Zhuang, Yong-Qiang Tu, Xiang Guo, Rui-Qi Si, Shuang-Hu Wang |
| المصدر: | Angewandte Chemie International Edition. 59:21954-21958 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Indole test, Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Chemistry, Aspidofractinine, Total synthesis, General Chemistry, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Catalysis, 0104 chemical sciences, Semipinacol rearrangement, Bischler–Napieralski reaction, Mannich reaction |
| الوصف: | A tandem Bischler-Napieralski/semipinacol rearrangement reaction has been developed for the purpose of assembling a bis(spirocyclic) indole framework, a privileged structural unit of aspidofractinine-type monoterpenoid indole alkaloids, and was used in combination with a subsequent Mannich reaction to expeditiously construct the central bridged bicyclo[2.2.1]heptane ring system of these molecules with contiguous quaternary centers. The development of this novel strategy culminated in the collective total synthesis of four aspidofractinine alkaloids. |
| تدمد: | 1521-3773 1433-7851 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec810bdc124869f7b7d54ed068d388d1 https://doi.org/10.1002/anie.202009238 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ec810bdc124869f7b7d54ed068d388d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15213773 14337851 |
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