Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review)
| العنوان: | Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review) |
|---|---|
| المؤلفون: | Jaikee Kumar Singh, Omar A Al Obeed, Sandeep Kumar Srivastava, Rehan Ahmad, Amoolya Wunnava, Maha Abdulla |
| المصدر: | International Journal of Molecular Medicine |
| بيانات النشر: | D.A. Spandidos, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, colorectal cancer, Disease, MLH1, DNA Mismatch Repair, Targeted therapy, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, Internal medicine, Genetics, medicine, Humans, metastasis, Young adult, neoplasms, Early Detection of Cancer, Germ-Line Mutation, business.industry, Cancer, General Medicine, Articles, medicine.disease, mutations, targeted therapy, digestive system diseases, signaling pathways, 030104 developmental biology, 030220 oncology & carcinogenesis, Colorectal Neoplasms, business, Signal Transduction |
| الوصف: | Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second most common cause of cancer‑related mortality globally. The American Cancer Society predicted that approximately 147,950 individuals would be diagnosed with CRC, out of which 53,200 individuals would succumb to the disease in the USA alone in 2020. CRC‑related mortality ranks third among both males and females in the USA. CRC arises from 3 major pathways: i) The adenoma‑carcinoma sequence; ii) serrated pathway; and iii) the inflammatory pathway. The majority of cases of CRC are sporadic and result from risk factors, such as a sedentary lifestyle, obesity, processed diets, alcohol consumption and smoking. CRC is also a common preventable cancer. With widespread CRC screening, the incidence and mortality from CRC have decreased in developed countries. However, over the past few decades, CRC cases and mortality have been on the rise in young adults (age,lt;50 years). In addition, CRC cases are increasing in developing countries with a low gross domestic product (GDP) due to lifestyle changes. CRC is an etiologically heterogeneous disease classified by tumor location and alterations in global gene expression. Accumulating genetic and epigenetic perturbations and aberrations over time in tumor suppressor genes, oncogenes and DNA mismatch repair genes could be a precursor to the onset of colorectal cancer. CRC can be divided as sporadic, familial, and inherited depending on the origin of the mutation. Germline mutations in APC and MLH1 have been proven to play an etiological role, resulting in the predisposition of individuals to CRC. Genetic alterations cause the dysregulation of signaling pathways leading to drug resistance, the inhibition of apoptosis and the induction of proliferation, invasion and migration, resulting in CRC development and metastasis. Timely detection and effective precision therapies based on the present knowledge of CRC is essential for successful treatment and patient survival. The present review presents the CRC incidence, risk factors, dysregulated signaling pathways and targeted therapies. |
| اللغة: | English |
| تدمد: | 1791-244X 1107-3756 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb61d79b5787bebd584e19b13a08a30 http://europepmc.org/articles/PMC7834960 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ecb61d79b5787bebd584e19b13a08a30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1791244X 11073756 |
|---|