Lung Cancer Stem Cell Lose Their Stemness Default State after Exposure to Microgravity
| العنوان: | Lung Cancer Stem Cell Lose Their Stemness Default State after Exposure to Microgravity |
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| المؤلفون: | Alberto Ricci, Alessia Noto, Gennaro Ciliberto, Claudia De Vitis, Maria Grazia Masiello, Pierpaolo Coluccia, Enrico Giarnieri, Rita Mancini, Sara Proietti, Alessandra Cucina, Maria Rosaria Giovagnoli, Mariano Bizzarri, Maria Elena Pisanu |
| المصدر: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| بيانات النشر: | Hindawi Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Homeobox protein NANOG, Cellular pathology, Pathology, medicine.medical_specialty, Lung Neoplasms, Article Subject, phenotype, proliferation, Cellular differentiation, lcsh:Medicine, Apoptosis, General Biochemistry, Genetics and Molecular Biology, simulated microgravity, differentiation, genes, Cancer stem cell, Cell Line, Tumor, Spheroids, Cellular, Cell Adhesion, Humans, Medicine, Enzyme Assays, General Immunology and Microbiology, Weightlessness, business.industry, Cell Cycle, lcsh:R, DNA, Neoplasm, General Medicine, Aldehyde Dehydrogenase, Cell cycle, Flow Cytometry, Cell biology, Cell culture, Cancer cell, Neoplastic Stem Cells, Stem cell, business, Research Article |
| الوصف: | Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded. Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity. Our study provides evidence that a similar event occurs when cancer stem cells (CSCs) are cultured in microgravity. In the same time, a significant increase in apoptosis was recorded: those data point out that microgravity rescues CSCs from their relative quiescent state, inducing CSCs to lose their stemness features, as documented by the decrease in ALDH and the downregulation of both Nanog and Oct-4 genes. Those traits were stably acquired and preserved by CSCs when cells were placed again on a 1 g field. Studies conducted in microgravity on CSCs may improve our understanding of the fundamental role exerted by biophysical forces in cancer cell growth and function. |
| وصف الملف: | text/xhtml |
| تدمد: | 2314-6141 2314-6133 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdd594aa2048d11baedfa935e0f0924 https://doi.org/10.1155/2014/470253 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ecdd594aa2048d11baedfa935e0f0924 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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