Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy
العنوان: | Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy |
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المؤلفون: | Irina V. Guzhova, Maxim Shevtsov, Boris A. Margulis, Katerina M. Pankratova, Sergey V. Abkin |
المصدر: | International Journal of Hyperthermia. 29:399-408 |
بيانات النشر: | Informa UK Limited, 2013. |
سنة النشر: | 2013 |
مصطلحات موضوعية: | Cancer Research, biology, Physiology, Cancer Vaccines, Cell biology, Immune system, Antigen, Antigens, Neoplasm, Neoplasms, Physiology (medical), Chaperone (protein), Heat shock protein, Cancer cell, Extracellular, biology.protein, Animals, Humans, Cytotoxic T cell, HSP70 Heat-Shock Proteins, Intracellular |
الوصف: | Purpose: Heat shock protein 70 (HSPA family) is a multi-functional protein which protects individual cells from proteotoxic shock and the whole organism from microbial, viral and oncogenic pathogens. These diverse functions may depend upon ‘chaperone’ activity that allows Hsp70 to regulate the mechanism of damaged protein recovery or utilisation inside a cell and to be a potent adjuvant, stimulating immune activity against a variety of viral or tumour antigens. The aim of this review is to present recent data on specific roles of intracellular and extracellular Hsp70 in cancerous tissue.Conclusion: The data presented in this paper show that endogenous Hsp70 protects cancer cells of different origins from a variety of cytotoxic threats including cancer cell therapeutics. In contrast, however, Hsp70 released from stressed cancer cells can serve as a danger signal or may recruit cells responsible for the generation of innate and adaptive immune responses against tumour cells. |
تدمد: | 1464-5157 0265-6736 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed043bfa68e855e64c5b02d442b5e3f2 https://doi.org/10.3109/02656736.2013.807439 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....ed043bfa68e855e64c5b02d442b5e3f2 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 14645157 02656736 |
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