Variability in haemoglobin concentration by measurement tool and blood source: an analysis from seven countries
| العنوان: | Variability in haemoglobin concentration by measurement tool and blood source: an analysis from seven countries |
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| المؤلفون: | Sam Newton, Lynnette M. Neufeld, Ralph D Whitehead, Omar Dary, Rita Wegmüller, Megan Parker, Sonja Y. Hess, Aviva I Rappaport, Crystal D Karakochuk, Sorrel Namaste, Denish Moorthy, Leila M Larson |
| المصدر: | Journal of Clinical Pathology. 74:657-663 |
| بيانات النشر: | BMJ, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Concordance, Population, 030204 cardiovascular system & hematology, Veins, Pathology and Forensic Medicine, Hemoglobins, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Phlebotomy, Predictive Value of Tests, Pregnancy, Internal medicine, Epidemiology, medicine, Humans, education, Automation, Laboratory, Observer Variation, Blood Specimen Collection, education.field_of_study, Hematology, business.industry, Obstetrics, Infant, Reproducibility of Results, General Medicine, Venous blood, Blood collection, Middle Aged, Capillaries, Child, Preschool, 030220 oncology & carcinogenesis, Female, business, Nutritional science, Biomarkers, Blood Chemical Analysis, Blood sampling |
| الوصف: | ObjectiveWe explore factors such as the blood sampling site (capillary vs venous), the equipment (HemoCue vs automated haematology analyser) and the model of the HemoCue device (201+ vs 301) that may impact haemoglobin measurements in capillary and venous blood.MethodsEleven studies were identified, and bias, concordance and measures of diagnostic performance were assessed within each study.FindingsOur analysis included 11 studies from seven countries (Cambodia, India, The Gambia, Ghana, Laos, Rwanda and USA). Samples came from children, men, non-pregnant women and pregnant women. Mean bias ranged from −8.7 to 2.5 g/L in Cambodian women, 6.2 g/L in Laotian children, 2.4 g/L in Ghanaian women, 0.8 g/L in Gambian children 6–23 months and 1.4 g/L in Rwandan children 6–59 months when comparing capillary blood on a HemoCue to venous blood on a haematology analyser. Bias was 8.3 g/L in Indian non-pregnant women and 2.6 g/L in Laotian children and women and 1.5 g/L in the US population when comparing capillary to venous blood using a HemoCue. For venous blood measured on the HemoCue compared with the automated haematology analyser, bias was 5.3 g/L in Gambian pregnant women 18–45 years and 11.3 g/L in Laotian children 6–59 months.ConclusionOur analysis found large variability in haemoglobin concentration measured on capillary or venous blood and using HemoCue Hb 201+ or Hb 301 or automated haematology analyser. We cannot ascertain whether the variation is due to differences in the equipment, differences in capillary and venous blood, or factors affecting blood collection techniques. |
| تدمد: | 1472-4146 0021-9746 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0b225a76a6e055f44ccfddf5a97542 https://doi.org/10.1136/jclinpath-2020-206717 |
| رقم الأكسشن: | edsair.doi.dedup.....ed0b225a76a6e055f44ccfddf5a97542 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14724146 00219746 |
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