Molecular aspects of a novel HLA-A*02 allele (A*0297): the first HLA class I allele mutated at codon 232
| العنوان: | Molecular aspects of a novel HLA-A*02 allele (A*0297): the first HLA class I allele mutated at codon 232 |
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| المؤلفون: | Stanislav Miertus, Vladimir Frecer, Elena Garino, M. Berrino, Jan Miertus, Fabrizio Tondat, P. Caropreso, Francesca Bertinetto, Gina Mazzola, Antonio Amoroso |
| المصدر: | Tissue Antigens. 69:342-347 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Models, Molecular, new allele, Molecular Sequence Data, Immunology, Genes, MHC Class I, HLA-A*0297, major histocompatibility complex, molecular modelling, sequence-based typing, Human leukocyte antigen, Biology, medicine.disease_cause, Major histocompatibility complex, Biochemistry, Exon, HLA Antigens, Genetics, medicine, Humans, Immunology and Allergy, Allele, Codon, Alleles, Mutation, Polymorphism, Genetic, Base Sequence, HLA-A Antigens, Models, Genetic, Infant, Newborn, Nucleic acid sequence, General Medicine, Fetal Blood, Molecular biology, HLA-A, biology.protein, Female, CD8 |
| الوصف: | We describe a new HLA-A*02 allele, identified in a cord blood unit and in her mother. Nucleotide sequence analysis showed the presence of a new HLA-A*02 allele identical to HLA-A*02010101 except for a non-synonymous nucleotide exchange in exon 4 modifying codon 232 from GAG (Glu) to GAC (Asp). No other human leucocyte antigen class I allele sequenced so far shows this triplet at codon 232. The amino acid exchange affects a position that is part of the membrane proximal domain of class I major histocompatibility complex (MHC), designated alpha 3, and involved in the interaction with CD8 molecule. Using molecular modelling approach, the interactions between different subunits of the native and mutated forms of MHC-I resulted in relevant changes. |
| تدمد: | 1399-0039 0001-2815 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed515814e7dc2957c76e6e3beb102916 https://doi.org/10.1111/j.1399-0039.2007.00819.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ed515814e7dc2957c76e6e3beb102916 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13990039 00012815 |
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