Association of TNF-α polymorphisms (−857, −863 and −1031), TNF-α serum level and lipid profile with acne vulgaris
| العنوان: | Association of TNF-α polymorphisms (−857, −863 and −1031), TNF-α serum level and lipid profile with acne vulgaris |
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| المؤلفون: | Kanwal Nisar, Sara Mumtaz, Sana Shamim, Miroslav Blumenberg, Sidra Younis, Farah Deeba, Sabba Mehmood, Qamar Javed |
| المصدر: | Saudi Journal of Biological Sciences, Vol 28, Iss 11, Pp 6615-6620 (2021) Saudi Journal of Biological Sciences |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Linkage disequilibrium, IL-1, Interleukin-1, Apolipoprotein B, Acne severity, QH301-705.5, Population, AV, Acne vulgaris, TNFAlpha, LGL, Low glycemic load, Association, chemistry.chemical_compound, High-density lipoprotein, Polymorphism (computer science), Internal medicine, Medicine, Lipid Profile, TNF-α, Tumor necrosis factor alpha, Acne vulgaris, Biology (General), education, TC, Total cholesterol, OPD, Out-patient department, Acne, education.field_of_study, biology, medicine.diagnostic_test, business.industry, Cholesterol, HDL-C, High density lipoprotein cholesterol, medicine.disease, Endocrinology, chemistry, biology.protein, Original Article, C. acnes, Cutibacterium acnes, General Agricultural and Biological Sciences, business, Lipid profile, Polymorphisms, Apo-a, Apolipoprotein a, Acne types |
| الوصف: | Background Acne is an inflammatory condition principally affected by genetic and dietary factors. Investigation into functional polymorphisms of TNF-α gene and their association with acne vulgaris will be helpful in exploring genetic influence on skin immune mediated inflammatory events. In the present study, we analyzed association of TNF-α gene polymorphisms, its expression levels and lipid profiles in a large cohort of acne patients and controls. Methods We used PCR-RFLP to study association of TNF-α polymorphisms at -857C/T, -863C/A and -1031 T/C sites with acne vulgaris. Lipid profiles were measured using enzymatic end-point method. The serum levels of TNF-α and apolipoprotein a were measured using ELISA. NIH, LDlink was used to investigate patterns of linkage disequilibrium across south Asian reference genome (Punjabi from Lahore Pakistan). Results We found that TNF-α -863 polymorphism is strongly associated with acne in overall population as well as in gender and severity based groups of acne patients. Polymorphisms at -863 and -1031 position were in linkage disequilibrium. Importantly, TNF-α serum level was significantly increased in acne patients with severe disease symptoms. Furthermore, levels of total cholesterol (TC) and triglycerides (TG) were significantly increased, whereas high density lipoprotein cholesterol (HDL-C) level was significantly decreased in acne patients. The levels of apolipoprotein a varied widely in studied populations and no significant difference was found in the analyzed groups. Conclusion In conclusion, we found that TNF-α expression increases in acne patients affected by TNF-α polymorphisms, and that the lipid profile is specifically disrupted in acne patients. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed99e7737401b84ff856910f0140d959 http://www.sciencedirect.com/science/article/pii/S1319562X21006161 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ed99e7737401b84ff856910f0140d959 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |