Tumor load rather than contrast enhancement is associated with the visual function of children and adolescents with optic pathway glioma – a retrospective Magnetic Resonance Imaging study
| العنوان: | Tumor load rather than contrast enhancement is associated with the visual function of children and adolescents with optic pathway glioma – a retrospective Magnetic Resonance Imaging study |
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| المؤلفون: | Anna Kilian, Annette Aigner, Michèle Simon, Daniel J. Salchow, Cornelia Potratz, Ulrich-Wilhelm Thomale, Pablo Hernáiz Driever, Anna Tietze |
| المصدر: | Journal of Neuro-Oncology. 156:589-597 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Optic Nerve Glioma, Cancer Research, Neurofibromatosis 1, Adolescent, Neurology, Oncology, Contrast Media, Humans, Neurology (clinical), Child, Magnetic Resonance Imaging, Retrospective Studies, Tumor Burden |
| الوصف: | Introduction Optic pathway gliomas are often asymptomatic tumors occurring in children with neurofibromatosis type 1 (NF1 + OPG) or sporadically (spOPG). Treatment is usually prompted by visual loss and/or tumor progression on MRI. The aim of this study was to investigate the relationship between visual acuity (VA), tumor growth, and contrast enhancement to provide more distinct indications for the administration of gadolinium-based contrast agents. Methods Tumor load was retrospectively measured and enhancement semi-quantitatively scored on 298 MRIs of 35 patients (63% NF1 + OPG). Spearman rank correlation between tumor load and enhancement was calculated and a linear mixed model used to examine the influence of tumor load and enhancement on corresponding VA tests (LogMAR). Results The optic nerve width in NF1 + OPGs was strongly associated with VA (regression coefficient 0.75; confidence interval 0.61—0.88), but weakly with enhancement (0.06; −0.04—0.15). In spOPGs, tumor volume and optic nerve width were more relevant (0.31; −0.19—0.81 and 0.39; 0.05—0.73) than enhancement (0.09; −0.09—0.27). Conclusions Tumor load measures may be more relevant for the surveillance of optic pathway gliomas than enhancement, given that VA is the relevant outcome parameter. Regular contrast administration should therefore be questioned in these patients. |
| تدمد: | 1573-7373 0167-594X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede487bc5b5da933f21eb3b3d2177804 https://doi.org/10.1007/s11060-021-03941-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ede487bc5b5da933f21eb3b3d2177804 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737373 0167594X |
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