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The Angiotensin Type 1 Receptor Antagonist Losartan Prevents Ovariectomy-Induced Cognitive Dysfunction and Anxiety-Like Behavior in Long Evans Rats

التفاصيل البيبلوغرافية
العنوان: The Angiotensin Type 1 Receptor Antagonist Losartan Prevents Ovariectomy-Induced Cognitive Dysfunction and Anxiety-Like Behavior in Long Evans Rats
المؤلفون: Crystal A. West, Brittany L. Aguilar, Dexter L. Lee, Glenda V. Campos, Hong Ji, Kathryn Sandberg, Xie Wu, Rodrigo Cunha Alvim de Menezes, Aline M. A. de Souza, Patrick A. Forcelli
المصدر: Cellular and Molecular Neurobiology
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, Elevated plus maze, medicine.medical_specialty, Mean arterial pressure, Ovariectomy, Blood Pressure, Anxiety, Losartan, Receptor, Angiotensin, Type 1, Open field, Angiotensin Receptor Antagonists, Food Preferences, 03 medical and health sciences, Cellular and Molecular Neuroscience, Cognition, 0302 clinical medicine, Memory, Internal medicine, Animals, Medicine, Cognitive Dysfunction, Rats, Long-Evans, Cognitive decline, Maze Learning, Premature ovarian failure, Original Research, Behavior, Animal, business.industry, Body Weight, Uterus, Recognition, Psychology, Cell Biology, General Medicine, medicine.disease, Rats, Menopause, 030104 developmental biology, Endocrinology, Blood pressure, Ovariectomized rat, Postmenopausal, Female, business, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, medicine.drug
الوصف: Women who have bilateral oophorectomies prior to the age of natural menopause are at increased risk of developing mild cognitive decline, dementia, anxiety, and depressive type disorders. Clinical and animal studies indicate angiotensin type 1 receptor (AT1R) blockers (ARBs) have blood pressure (BP)-independent neuroprotective effects. To investigate the potential use of ARBs in normotensive women at increased risk of developing neurocognitive problems, we studied a rat model of bilateral oophorectomy. Long Evans rats were sham-operated (Sham) or ovariectomized (Ovx) at 3 months of age and immediately treated continuously with vehicle (Veh) or the ARB losartan (Los) for the duration of the experiment. In contrast to many hypertensive rat models, ovariectomy did not increase mean arterial pressure (MAP) in these normotensive rats. Ovariectomized rats spent less time in the open arms of the elevated plus maze (EPM) [(% total time): Veh, 34.1 ± 5.1 vs. Ovx, 18.7 ± 4.4; p
تدمد: 1573-6830
0272-4340
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf1736aef7fc1ac40c0090c19f6f8f8
https://doi.org/10.1007/s10571-019-00744-x
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....edf1736aef7fc1ac40c0090c19f6f8f8
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15736830
02724340