التفاصيل البيبلوغرافية
العنوان:
Selective non zinc binding inhibitors of MMP13
المؤلفون:
Michael James , Gordon A. Hamlin , Stefan Gerhardt , David Ryan , Nash Ian Alun , Attilla Ting , Stephen J. Norris , Galith Karoutchi , Chris De Savi , Neil Rankine , David J. Hargreaves , Christine M. Wood , Sarah V. Baker , Philip A. MacFaul , Andrew David Morley , Kostas Karabelas
المصدر:
Bioorganic & Medicinal Chemistry Letters . 21:4215-4219
بيانات النشر:
Elsevier BV, 2011.
سنة النشر:
2011
مصطلحات موضوعية:
Molecular model , medicine.drug_class , Stereochemistry , Clinical Biochemistry , Pharmaceutical Science , Stereoisomerism , Carboxamide , Matrix Metalloproteinase Inhibitors , Crystallography, X-Ray , Biochemistry , Structure-Activity Relationship , Catalytic Domain , Matrix Metalloproteinase 13 , Drug Discovery , Hydrolase , medicine , Structure–activity relationship , Protease Inhibitors , Binding site , Molecular Biology , Binding Sites , biology , Chemistry , Organic Chemistry , Zinc , Enzyme inhibitor , biology.protein , Molecular Medicine , Selectivity
الوصف:
Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfdcf46848c274f3946020e4941981e https://doi.org/10.1016/j.bmcl.2011.05.075
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....edfdcf46848c274f3946020e4941981e
قاعدة البيانات:
OpenAIRE
