Aerobic Exercise Training Prevents Insulin Resistance and Hepatic Lipid Accumulation in LDL Receptor Knockout Mice Chronically Fed a Low-Sodium Diet
| العنوان: | Aerobic Exercise Training Prevents Insulin Resistance and Hepatic Lipid Accumulation in LDL Receptor Knockout Mice Chronically Fed a Low-Sodium Diet |
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| المؤلفون: | Vanessa Del Bianco, Paula Ramos Pinto, Ubiratan Fabres Machado, Letícia G. Rodrigues, Guilherme da Silva Ferreira, Edna Regina Nakandakare, Marisa Passarelli, Sergio Catanozi, Ana Paula Garcia Bochi, Mychel R. P. T. Morais |
| المصدر: | Nutrients Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Nutrients, Vol 13, Iss 2174, p 2174 (2021) Volume 13 Issue 7 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, food.diet, Gene Expression, Citrate (si)-Synthase, Low sodium diet, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Insulin resistance, food, Internal medicine, Physical Conditioning, Animal, insulin resistance, medicine, Aerobic exercise, Animals, TX341-641, sodium restriction, Triglycerides, Mice, Knockout, Nutrition and Dietetics, medicine.diagnostic_test, Triglyceride, Nutrition. Foods and food supply, Body Weight, dyslipidemia, Sodium, Dietary, Diet, Sodium-Restricted, medicine.disease, Lipid Metabolism, Lipids, 030104 developmental biology, Endocrinology, aerobic exercise, chemistry, Liver, Receptors, LDL, LDL receptor, 030211 gastroenterology & hepatology, Lipid profile, DIETA ANIMAL, Dyslipidemia, Food Science, Lipoprotein |
| الوصف: | Background: A low-sodium (LS) diet reduces blood pressure, contributing to the prevention of cardiovascular diseases. However, intense dietary sodium restriction impairs insulin sensitivity and worsens lipid profile. Considering the benefits of aerobic exercise training (AET), the effect of LS diet and AET in hepatic lipid content and gene expression was investigated in LDL receptor knockout (LDLr-KO) mice. Methods: Twelve-week-old male LDLr-KO mice fed a normal sodium (NS) or LS diet were kept sedentary (S) or trained (T) for 90 days. Body mass, plasma lipids, insulin tolerance testing, hepatic triglyceride (TG) content, gene expression, and citrate synthase (CS) activity were determined. Results were compared by 2-way ANOVA and Tukey’s post-test. Results: Compared to NS, LS increased body mass and plasma TG, and impaired insulin sensitivity, which was prevented by AET. The LS-S group, but not the LS-T group, presented greater hepatic TG than the NS-S group. The LS diet increased the expression of genes related to insulin resistance (ApocIII, G6pc, Pck1) and reduced those involved in oxidative capacity (Prkaa1, Prkaa2, Ppara, Lipe) and lipoprotein assembly (Mttp). Conclusion: AET prevented the LS-diet-induced TG accumulation in the liver by improving insulin sensitivity and the expression of insulin-regulated genes and oxidative capacity. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee97450f94528d0b9ce455441dd31279 https://pubmed.ncbi.nlm.nih.gov/34202724 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ee97450f94528d0b9ce455441dd31279 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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