Objectives. The objective of the paper is to present the outcomes of the HepHIV 2019 conference, held in Bucharest under the Romanian EU Presidency and focusing on challenges of timely and integrated testing and care. Methods. The conference programme was put together by the organizing committee. It consisted of invited talks and peer-reviewed abstracts. Results. In all, 65 abstracts from 20 countries were presented during the conference, which had nearly 250 delegates, including high-profile political representation. The conference highlighted the need to shift towards further disease integration because of the epidemiological characteristics of the hepatitis B (HBV), hepatitis C (HCV), HIV, sexually transmitted infection (STIs) and tuberculosis (TB) epidemics in the WHO European region. Integration should be a priority in the response to the epidemics to better reach key populations and to ensure better testing coverage. This relates to both the integration of services in shared care models and the integration of different settings and stakeholders in national strategies. Conclusions. The conference demonstrated the need for greater political support for the policy changes required to implement integration. Testing normalization efforts are key to maximizing the impact of integration efforts. The conference call to action can help to guide developments in testing and linkage-to-care interventions across the European region. The HepHIV 2019 Bucharest Conference was co-funded with the Health Programme of the European Union and the EU Health Project Symposium; Integrated Testing and Synergies was funded by the Health Programme of the European Union. The HepHIV 2019 Bucharest Conference was funded by the HIV in Europe/EuroTEST Initiative that received sponsorship funds for this purpose from Gilead, Merck MSD, ViiV Healthcare, Abbvie, Autotest Santé (AAZ-LMB), Cepheid, InTec, OraSure and SH:24. The funders had no role in the study design, analysis, decision to publish, or preparation of the manuscript.