Phosphine-catalyzed divergent domino processes between γ-substituted allenoates and carbonyl-activated alkenes
| العنوان: | Phosphine-catalyzed divergent domino processes between γ-substituted allenoates and carbonyl-activated alkenes |
|---|---|
| المؤلفون: | Mingyue Wu, Zhaobin Han, Huanzhen Ni, Nengzhong Wang, Kuiling Ding, Yixin Lu |
| المصدر: | Chemical Science. 13:3161-3168 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Chemistry |
| الوصف: | Highly enantioselective and chemodivergent domino reactions between γ-substituted allenoates and activated alkenes have been developed. In the presence of NUSIOC-Phos, triketone enone substrates smoothly reacted with γ-substituted allenoates to form bicyclic furofurans in good yields with high stereoselectivities. Alternatively, the reaction between diester-activated enone substrates and γ-substituted allenoates formed chiral conjugated 1,3-dienes in good yields with excellent enantioselectivities. Notably, by employing substrates with subtle structural difference, under virtually identical reaction conditions, we were able to access two types of chiral products, which are of biological relevance and synthetic importance. |
| تدمد: | 2041-6539 2041-6520 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef41ea494625dec721728a5338496c63 https://doi.org/10.1039/d1sc06364b |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ef41ea494625dec721728a5338496c63 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20416539 20416520 |
|---|