At similar weight loss, dietary composition determines the degree of glycemic improvement in diet-induced obese C57BL/6 mice
| العنوان: | At similar weight loss, dietary composition determines the degree of glycemic improvement in diet-induced obese C57BL/6 mice |
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| المؤلفون: | João Paulo Monteiro Carvalho Mori da Cunha, Chantal Mathieu, Bart Van der Schueren, Ann Mertens, Ann Meulemans, Miranda van der Ende, Katrien Corbeels, Pierre Bedossa, Lut Overbergh, Christophe Matthys, Ina Gesquiere, Roman Vangoitsenhoven, Schalk Van der Merwe, Matthias Lannoo |
| المصدر: | PLoS ONE PLoS ONE, Vol 13, Iss 7, p e0200779 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood Glucose, Male, Steatosis, Physiology, Adipose tissue, lcsh:Medicine, Mice, Obese, Pathology and Laboratory Medicine, Biochemistry, Fats, Cytopathology, chemistry.chemical_compound, Eating, Mice, 0302 clinical medicine, Endocrinology, Weight loss, Animal Cells, Adipocyte, Adipocytes, Medicine and Health Sciences, Medicine, Glucose homeostasis, Homeostasis, lcsh:Science, Adiposity, Connective Tissue Cells, 2. Zero hunger, INSULIN-RESISTANCE, Multidisciplinary, Liver Diseases, Fatty liver, Lipids, Type 2 Diabetes, Multidisciplinary Sciences, ADIPOSE-TISSUE, Adipose Tissue, Physiological Parameters, Connective Tissue, Body Composition, Science & Technology - Other Topics, medicine.symptom, Cellular Types, Anatomy, Research Article, medicine.medical_specialty, Endocrine Disorders, Adipose Tissue, White, POUNDS LOST, 030209 endocrinology & metabolism, Gastroenterology and Hepatology, Calorimetry, Diet, High-Fat, 03 medical and health sciences, Internal medicine, Glucose Intolerance, Weight Loss, Diabetes Mellitus, Animals, Obesity, Caloric Restriction, Nutrition, Inflammation, Science & Technology, business.industry, lcsh:R, Body Weight, Biology and Life Sciences, Nutrients, Cell Biology, medicine.disease, Dietary Fats, Diet, Fatty Liver, Mice, Inbred C57BL, 030104 developmental biology, Glucose, Biological Tissue, chemistry, Diet and Type 2 Diabetes, CLINICAL-PRACTICE, FAT, Anatomical Pathology, Metabolic Disorders, lcsh:Q, business, Diet-induced obese |
| الوصف: | BACKGROUND: Achieving weight loss is the cornerstone of the treatment of the metabolic consequences of obesity, in particular of glucose intolerance. OBJECTIVE: To determine whether improvement in glucose control depends on dietary macronutrient composition of the diet at identical weight loss. MATERIALS AND METHODS: Twenty-two weeks old diet-induced obese C57BL/6 mice lost weight through caloric restriction on normal chow (R-NC) or high fat diet (R-HF). Control mice were fed normal chow (LEAN) or high fat diet (OBESE) ad libitum. Body weight and composition were assessed after 8 weeks of dietary intervention. Glucose homeostasis was evaluated by intraperitoneal glucose tolerance tests (IPGTT). Epididymal white adipose (eWAT) and hepatic tissues were analyzed by immunohistochemistry and RT-qPCR. RESULTS: By 30 weeks of age, the body weight of the mice on R-NC (31.6±1.7g, mean±SEM) and R-HF (32.3±0.9g) was similar to LEAN mice (31.9±1.4g), while OBESE mice weighed 51.7±2.4g. Glucose tolerance in R-NC was better than in LEAN mice (69% AUC IPGTT, P 0.0168) whereas R-HF mice remained significantly less glucose tolerant (125% AUC IPGTT, P 0.0279 vs LEAN), despite identical weight loss. The eWAT pads and adipocyte size were similar in LEAN and R-NC mice, while the eWAT pad size of R-HF was 180% of R-NC (P < 0.0001) and the average adipocyte size of R-HF mice was 134% of R-NC fed mice (P 0.0285). No LEAN or R-NC mice had hepatic steatosis, in contrast to 28.6% of R-HF mice. Compared to OBESE mice, inflammatory markers were lower in eWAT and liver tissue of R-NC, but not in R-HF mice. Measures of visceral adiposity correlated well with glucose tolerance parameters. CONCLUSIONS: In mice, caloric restriction on a normal chow diet improved glucose tolerance significantly more when identical weight loss was achieved on a high fat diet. ispartof: PLOS ONE vol:13 issue:7 ispartof: location:United States status: published |
| وصف الملف: | Electronic-eCollection |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03a8f4d9ab14843039fe25f092ddbb5 https://pubmed.ncbi.nlm.nih.gov/30036374 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f03a8f4d9ab14843039fe25f092ddbb5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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