The logic of single-cell projections from visual cortex
| العنوان: | The logic of single-cell projections from visual cortex |
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| المؤلفون: | Thomas D. Mrsic-Flogel, Yunyun Han, Justus M. Kebschull, Devon Cowan, Fabia Imhof, Anthony M. Zador, Robert A. A. Campbell |
| المصدر: | Nature. 556:51-56 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Sensory processing, medicine.medical_treatment, Biology, Brain mapping, Article, Fluorescence, Mice, 03 medical and health sciences, 0302 clinical medicine, Projection (mathematics), Single-cell analysis, Extrastriate cortex, Neural Pathways, medicine, Biological neural network, Animals, Visual Cortex, Brain Mapping, Multidisciplinary, High-Throughput Nucleotide Sequencing, Neuroanatomical Tract-Tracing Techniques, Axons, Mice, Inbred C57BL, 030104 developmental biology, Visual cortex, medicine.anatomical_structure, nervous system, Female, Single-Cell Analysis, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Neocortical areas communicate through extensive axonal projections, but the logic of information transfer remains poorly understood, because the projections of individual neurons have not been systematically characterized. It is not known whether individual neurons send projections only to single cortical areas or distribute signals across multiple targets. Here we determine the projection patterns of 591 individual neurons in the mouse primary visual cortex using whole-brain fluorescence-based axonal tracing and high-throughput DNA sequencing of genetically barcoded neurons (MAPseq). Projections were highly diverse and divergent, collectively targeting at least 18 cortical and subcortical areas. Most neurons targeted multiple cortical areas, often in non-random combinations, suggesting that sub-classes of intracortical projection neurons exist. Our results indicate that the dominant mode of intracortical information transfer is not based on 'one neuron-one target area' mapping. Instead, signals carried by individual cortical neurons are shared across subsets of target areas, and thus concurrently contribute to multiple functional pathways. |
| تدمد: | 1476-4687 0028-0836 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03ecbf0ba4dab4f16e2495a6c78607b https://doi.org/10.1038/nature26159 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f03ecbf0ba4dab4f16e2495a6c78607b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764687 00280836 |
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