High density of REC 8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation
| العنوان: | High density of |
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| المؤلفون: | Hjalmar Brismar, Hans Blom, Abrahan Hernández-Hernández, Anna Kouznetsova, Otto Manneberg, Christer Höög, Ana Agostinho, Robin van Schendel |
| المصدر: | EMBO reports EMBO Reports, 17(6), 901-913 |
| بيانات النشر: | EMBO, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Chromosomal Proteins, Non-Histone, cohesin, Cell Cycle Proteins, Sister chromatid exchange, Chromatids, Biochemistry, Chromosome segregation, Mice, 03 medical and health sciences, 0302 clinical medicine, Spermatocytes, super-resolution microscopy, Chromosome Segregation, Genetics, Animals, Sister chromatids, News & Views, Molecular Biology, Mice, Knockout, Cohesin, Synaptonemal Complex, Chemistry, Synapsis, Nuclear Proteins, Articles, Phosphoproteins, sister chromatid cohesion, Cell biology, Establishment of sister chromatid cohesion, Protein Subunits, Chromosome Pairing, Meiosis, Synaptonemal complex, 030104 developmental biology, Chromatid, biological phenomena, cell phenomena, and immunity, Sister Chromatid Exchange, 030217 neurology & neurosurgery |
| الوصف: | During meiosis, a specialized chromosome structure is assembled to promote pairing/synapsis of homologous chromosomes and meiotic recombination, a process yielding chiasmata between homologs to ensure accurate segregation. Meiosis‐specific cohesin complexes mediating sister chromatid cohesion play pivotal roles in almost all these events, including synaptonemal complex (SC) formation. In this issue of EMBO Reports, Agostinho and colleagues have examined chromosome axes and SC structures by taking advantage of a hypomorphic Stag3 mutant in which the levels of the cohesin subunit REC8 are partly reduced 6. Using super‐resolution microscopy, the authors illuminate previously unforeseen chromosome axis structures, showing locally separated axes in regions where REC8 is absent, regardless of RAD21L or RAD21 cohesin localization. Furthermore, they assessed the relationship between sister chromatid cohesion and inter‐sister SC formation, demonstrating that “axial opening” in the REC8‐free region is accompanied by illegitimate SC formation between sister chromatids. This study highlights the physiological importance of REC8 in sister chromatid cohesion and proper SC formation during meiosis, suggesting a new model in which a high density of REC8 deposition along the chromosome prevents illegitimate inter‐sister SC formation. |
| تدمد: | 1469-3178 1469-221X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f044e75dccbd3279c7b258219a690cb1 https://doi.org/10.15252/embr.201642030 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f044e75dccbd3279c7b258219a690cb1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14693178 1469221X |
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