Beneficial Effects of Blueberries in Experimental Autoimmune Encephalomyelitis
| العنوان: | Beneficial Effects of Blueberries in Experimental Autoimmune Encephalomyelitis |
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| المؤلفون: | Junping Xin, Douglas L. Feinstein, Stanley A. Lorens, Susan O. McGuire, Matthew J. Hejna |
| المصدر: | Journal of Agricultural and Food Chemistry. 60:5743-5748 |
| بيانات النشر: | American Chemical Society (ACS), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Encephalomyelitis, Autoimmune, Experimental, Food Handling, Encephalomyelitis, Blueberry Plants, Inflammation, Neuroprotection, Mice, Myelin, medicine, Animals, Myelin Sheath, Autoimmune disease, business.industry, Multiple sclerosis, Experimental autoimmune encephalomyelitis, General Chemistry, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Freeze Drying, medicine.anatomical_structure, Spinal Cord, Fruit, Immunology, Experimental pathology, Female, medicine.symptom, General Agricultural and Biological Sciences, business |
| الوصف: | Experimental autoimmune encephalomyelitis (EAE) is an animal model of autoimmune disease that presents with pathological and clinical features similar to those of multiple sclerosis (MS) including inflammation and neurodegeneration. This study investigated whether blueberries, which possess immunomodulatory, anti-inflammatory, and neuroprotective properties, could provide protection in EAE. Dietary supplementation with 1% whole, freeze-dried blueberries reduced disease incidence by >50% in a chronic EAE model (p < 0.01). When blueberry-fed mice with EAE were compared with control-fed mice with EAE, blueberry-fed mice had significantly lower motor disability scores (p = 0.03) as well as significantly greater myelin preservation in the lumbar spinal cord (p = 0.04). In a relapsing-remitting EAE model, blueberry-supplemented mice showed improved cumulative and final motor scores compared to control diet-fed mice (p = 0.01 and 0.03, respectively). These data demonstrate that blueberry supplementation is beneficial in multiple EAE models, suggesting that blueberries, which are easily administered orally and well-tolerated, may provide benefit to MS patients. |
| تدمد: | 1520-5118 0021-8561 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04c383aa0982c1854760b8a42cf75a3 https://doi.org/10.1021/jf203611t |
| رقم الأكسشن: | edsair.doi.dedup.....f04c383aa0982c1854760b8a42cf75a3 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205118 00218561 |
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