Metabolomic analysis of uremic pruritus in patients on hemodialysis
| العنوان: | Metabolomic analysis of uremic pruritus in patients on hemodialysis |
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| المؤلفون: | Christian G. Bolanos, Timothy W. Meyer, Tammy L. Sirich, Nhat M. Pham, Robert D. Mair |
| المصدر: | PLoS ONE PLoS ONE, Vol 16, Iss 2, p e0246765 (2021) |
| بيانات النشر: | Public Library of Science, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Metabolic Analysis, Male, Physiology, medicine.medical_treatment, 030232 urology & nephrology, Social Sciences, Kidney, Gastroenterology, Biochemistry, Hemoglobins, 0302 clinical medicine, Mathematical and Statistical Techniques, Surveys and Questionnaires, Blood plasma, Medicine and Health Sciences, Psychology, Bile, Renal Insufficiency, skin and connective tissue diseases, Principal Component Analysis, Multidisciplinary, biology, integumentary system, Statistics, Phosphorus, Middle Aged, Body Fluids, Bioassays and Physiological Analysis, Blood, Nephrology, Physical Sciences, Metabolome, Medicine, Sensory Perception, Female, Hemodialysis, Anatomy, Research Article, medicine.medical_specialty, Uremic pruritus, Visual analogue scale, Science, Research and Analysis Methods, Blood Plasma, 03 medical and health sciences, Renal Dialysis, Internal medicine, Albumins, Medical Dialysis, medicine, Metabolomics, Humans, Statistical Methods, Dialysis, Aged, Uremia, business.industry, Pruritus, Albumin, Cognitive Psychology, Kidney metabolism, Biology and Life Sciences, Kidneys, Renal System, medicine.disease, Ferritin, body regions, 030104 developmental biology, Metabolism, Multivariate Analysis, Ferritins, biology.protein, Cognitive Science, Perception, Calcium, business, Mathematics, Neuroscience |
| الوصف: | Pruritus is a common debilitating symptom experienced by hemodialysis patients. Treatment is difficult because the cause of uremic pruritus is not known. This study addressed the hypothesis that pruritus is caused by solutes that accumulate in the plasma when the kidneys fail. We sought to identify solutes responsible for uremic pruritus using metabolomic analysis to compare the plasma of hemodialysis patients with severe pruritus versus mild/no pruritus. Pruritus severity in hemodialysis patients was assessed using a 100-mm visual analogue scale (VAS), with severe pruritus defined as >70 mm and mild/no pruritus defined as urea, and serum levels of calcium, phosphorus, PTH, albumin, ferritin, and hemoglobin were similar in the Itch and No Itch patients. Metabolomic analysis identified 1,548 solutes of which 609 were classified as uremic. No difference in the plasma or plasma ultrafiltrate levels of any solute or group of solutes was found between the Itch and No Itch patients. Metabolomic analysis of hemodialysis patients did not reveal any solutes associated with pruritus. A limitation of metabolomic analysis is that the solute of interest may not be included in the metabolomic platform’s chemical library. A role for uremic solutes in pruritus remains to be established. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05563d3d3dc3ab442f2e52ad3d54a1d http://europepmc.org/articles/PMC7880487 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f05563d3d3dc3ab442f2e52ad3d54a1d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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