Impact of tissue characteristics on luminal narrowing of mild angiographic coronary stenosis: assessment of integrated backscatter intravascular ultrasound
| العنوان: | Impact of tissue characteristics on luminal narrowing of mild angiographic coronary stenosis: assessment of integrated backscatter intravascular ultrasound |
|---|---|
| المؤلفون: | Tomonori Segawa, Taro Minagawa, Toshiyuki Noda, Shinya Minatoguchi, Makoto Iwama, Masanori Kawasaki, Sachiro Watanabe, Kazuhiko Nishigaki, Shinichiro Tanaka |
| المصدر: | Heart and Vessels. 29:750-760 |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Coronary Angiography, Severity of Illness Index, Coronary artery disease, Angina, Japan, Internal medicine, Intravascular ultrasound, medicine, Humans, Angina, Stable, Ultrasonography, Interventional, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Coronary Stenosis, Odds ratio, Middle Aged, medicine.disease, Coronary Vessels, Plaque, Atherosclerotic, Confidence interval, Cardiac surgery, Stenosis, medicine.anatomical_structure, Disease Progression, Cardiology, Female, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, Artery |
| الوصف: | Integrated backscatter intravascular ultrasound (IB-IVUS) is a useful method for analyzing coronary plaque tissue. We evaluated whether tissue composition determined using IB-IVUS is associated with the progression of stenosis in coronary angiography. Sixty-three nontarget coronary lesions in 63 patients with stable angina were evaluated using conventional IVUS and IB-IVUS. IB-IVUS images were analyzed at 1-mm intervals for a length of 10 mm. After calculating the relative areas of the tissue components using the IB-IVUS system, fibrous volume (FV) and lipid volume (LV) were calculated through integration of the slices, after which percentages of per-plaque volume (%FV/PV, %LV/PV) and per-vessel volume (%FV/VV, %LV/VV) were calculated. Progression of coronary stenosis was interpreted from the increase in percent diameter stenosis (%DS) from baseline to the follow-up period (6-9 months) using quantitative coronary angiography. %DS was 24.1 ± 12.8 % at baseline and 23.2 ± 13.7 % at follow-up. Using IB-IVUS, LV was 31.7 ± 10.5 mm(3), and %LV/PV and %LV/VV were 45.6 ± 10.3 % and 20.2 ± 6.0 %, respectively. FV, %FV/PV, and %FV/VV were 35.5 ± 12.1 mm(3), 52.1 ± 9.5 %, and 23.4 ± 7.1 %, respectively. The change in %DS was -0.88 ± 7.25 % and correlated closely with %LV/VV (r = 0.27, P = 0.03) on simple regression. Multivariate regression after adjustment for potentially confounding risk factors showed %LV/VV to be correlated independently with changes in %DS (r = 0.42, P = 0.02). Logistic regression analysis after adjusting for confounding coronary risk factors showed LV (odds ratio 1.08; 95 % confidence interval 1.01-1.16; P = 0.03) and %LV/VV (odds ratio 1.13; 95 % confidence interval 1.01-1.28; P = 0.03) to be independent predictors of the progression of angiographic coronary stenosis. Our findings suggest that angiographic luminal narrowing of the coronary artery is likely associated with tissue characteristics. IB-IVUS may provide information about the natural progression of luminal narrowing in coronary stenosis. |
| تدمد: | 1615-2573 0910-8327 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f060491b740897eb4fb8193ee1c01974 https://doi.org/10.1007/s00380-013-0428-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f060491b740897eb4fb8193ee1c01974 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16152573 09108327 |
|---|