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Adolescent cognitive function and incident early-onset type 2 diabetes

التفاصيل البيبلوغرافية
العنوان: Adolescent cognitive function and incident early-onset type 2 diabetes
المؤلفون: Deborah Novick, Hertzel C. Gerstein, Estela Derazne, Miri Lutski, Cole D. Bendor, Ofri Mosenzon, Orit Pinhas-Hamiel, Aya Bardugo, Itamar Raz, Arnon Afek, Gilad Twig, Tali Cukierman-Yaffe, Inbar Zucker, Dorit Tzur
المصدر: EClinicalMedicine, Vol 41, Iss, Pp 101138-(2021)
EClinicalMedicine
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
مصطلحات موضوعية: education.field_of_study, Medicine (General), Adolescent, business.industry, Population, Cognition, Type 2 diabetes, General Medicine, Cognitive scores, Logistic regression, medicine.disease, Cognitive subdomains, R5-920, Cohort, medicine, Mathematical ability, Effects of sleep deprivation on cognitive performance, education, business, Socioeconomic status, Demography, Research Paper
الوصف: Background Cognitive function among apparently healthy adolescents has been associated with cardiovascular morbidity and mortality. We examined the relationship between global and subdomain cognitive scores in adolescence and early-onset type 2 diabetes (T2D) in men and women. Methods A nationwide, population-based study of 971,677 Israeli born adolescents (56% men; mean age 17.4 years) who were medically examined and their cognitive performance was assessed before compulsory military service during 1992–2010. Data included global and subdomain cognitive Z-scores (problem-solving, verbal abstraction and categorization, verbal comprehension, and mathematical abilities). Data were linked to the Israeli National Diabetes Registry. The relations between global and subdomain scores and incident T2D was determined using Cox proportional hazard models and logistic regression models. Analyses were conducted separately for men and women. Findings During 16,095,122 person-years, 3,570 individuals developed T2D. After adjustment, those in the low compared to the high quintile of global cognitive Z-score had the highest risk for T2D; HR 2.46, (95% CI 2.10–2.88) for men and 2.33 (95% CI 1.88–2.89) for women. A one-unit lower global cognitive Z-score was associated with 1.41 (95% CI 1.34–1.48) and 1.46 (95% CI 1.36–1.56) increased risks for men and women, respectively. The relationship was noted for the cognitive subdomains scores as well as for the global cognitive score, with no heterogeneity across cognitive subdomains. Interpretation This large nationally representative cohort suggests relationship between global, as well as subdomain cognitive scores in late adolescence, and incident early onset T2D in both sexes, which was independent of socioeconomic status. Funding None.
اللغة: English
تدمد: 2589-5370
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0930db12b5bce18af6fbe5f43dc2c87
http://www.sciencedirect.com/science/article/pii/S2589537021004181
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....f0930db12b5bce18af6fbe5f43dc2c87
قاعدة البيانات: OpenAIRE
الوصف
تدمد:25895370