Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leoneans
| العنوان: | Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leoneans |
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| المؤلفون: | Augustine Goba, John Demby Sandi, Luis M. Branco, Megan L. Heinrich, Sophia A. Koval, Mambu Momoh, Karissa Chao, Patricia Snarski, Duane J. Bush, Andrew R. Hoffmann, Alexandra Melton, Nell G. Bond, Antoinette R. Bell-Kareem, Irina Aimukanova, Robert J. Samuels, Matthew L. Boisen, Rodrigo Borrega, Jaikin E Harrell, Lansana Kanneh, Anatoliy P. Koval, Megan M. Rowland, Whitney N. Phinney, Zoe L. Branco, Robert F. Garry, Pardis C. Sabeti, Debra Elliott, Diana K. S. Nelson, Kristian G. Andersen, Dahlene N. Fusco, James E. Robinson, Kaylynn J. Genemaras, Lilia I. Melnik, Raju Lathigra, Jeffrey G. Shaffer, Michael Gbakie, Julie A. Rouelle, Ashley A. Smira, Allison R. Smither, John S. Schieffelin, Gilberto Sabino-Santos, Don Grant, Arnaud Drouin |
| المصدر: | Viruses, Vol 13, Iss 2325, p 2325 (2021) Viruses Viruses; Volume 13; Issue 11; Pages: 2325 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, sub-Saharan Africa, Cross Protection, viruses, COVID-19 caseloads and deaths, Blood Donors, severe acute respiratory syndrome coronavirus-2, medicine.disease_cause, Antibodies, Viral, Serology, Epitopes, Pandemic, Medicine, Lassa fever, Antigens, Viral, Coronavirus, education.field_of_study, biology, Alphacoronavirus, virus diseases, recombinant antigens, pre-existing immunity to coronaviruses, enzyme-linked immunosorbent assays, pseudovirus neutralizing antibodies, Middle Eastern respiratory syndrome coronavirus, QR1-502, Infectious Diseases, Middle East Respiratory Syndrome Coronavirus, Female, Antibody, Population, Cross Reactions, Microbiology, Article, Sierra leone, Sierra Leone, Betacoronavirus, Age Distribution, Immunity, Virology, Coronavirus Nucleocapsid Proteins, Humans, Viral Pseudotyping, education, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Phosphoproteins, Antibodies, Neutralizing, United States, biology.protein, business |
| الوصف: | Many countries in sub-Saharan Africa have experienced lower COVID-19 caseloads and fewer deaths than countries in other regions worldwide. Under-reporting of cases and a younger population could partly account for these differences, but pre-existing immunity to coronaviruses is another potential factor. Blood samples from Sierra Leonean Lassa fever and Ebola survivors and their contacts collected before the first reported COVID-19 cases were assessed using enzyme-linked immunosorbent assays for the presence of antibodies binding to proteins of coronaviruses that infect humans. Results were compared to COVID-19 subjects and healthy blood donors from the United States. Prior to the pandemic, Sierra Leoneans had more frequent exposures than Americans to coronaviruses with epitopes that cross-react with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), SARS-CoV, and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). The percentage of Sierra Leoneans with antibodies reacting to seasonal coronaviruses was also higher than for American blood donors. Serological responses to coronaviruses by Sierra Leoneans did not differ by age or sex. Approximately a quarter of Sierra Leonian pre-pandemic blood samples had neutralizing antibodies against SARS-CoV-2 pseudovirus, while about a third neutralized MERS-CoV pseudovirus. Prior exposures to coronaviruses that induce cross-protective immunity may contribute to reduced COVID-19 cases and deaths in Sierra Leone. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1999-4915 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15daa47dc19be47c7424b8c27b8f2d1 https://www.mdpi.com/1999-4915/13/11/2325 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f15daa47dc19be47c7424b8c27b8f2d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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