Variation and Interdependencies of Human Milk Macronutrients, Fatty Acids, Adiponectin, Insulin, and IGF-II in the European PreventCD Cohort
| العنوان: | Variation and Interdependencies of Human Milk Macronutrients, Fatty Acids, Adiponectin, Insulin, and IGF-II in the European PreventCD Cohort |
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| المؤلفون: | Katharina J. Werkstetter, M. L. Mearin, Franca F. Kirchberg, Christian Hellmuth, Gemma Castillejo, Maria Grunewald, Sabine L. Vriezinga, María Roca, Renata Auricchio, Isabel Polanco, Ilma Rita Korponay-Szabó, Hans Demmelmair, Berthold Koletzko |
| المساهمون: | Grunewald, Maria, Hellmuth, Christian, Kirchberg, Franca F, Mearin, Maria Luisa, Auricchio, Renata, Castillejo, Gemma, Korponay-Szabo, Ilma R, Polanco, Isabel, Roca, Maria, Vriezinga, Sabine L, Werkstetter, Katharina, Koletzko, Berthold, Demmelmair, Hans |
| المصدر: | Nutrients, Vol 11, Iss 9, p 2034 (2019) Nutrients r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Volume 11 Issue 9 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Time Factors, country, medicine.medical_treatment, Breastfeeding, Palmitic acid, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Lactation, fat, Insulin, 2. Zero hunger, chemistry.chemical_classification, education.field_of_study, Nutrition and Dietetics, Postpartum Period, human milk, Milk Proteins, 3. Good health, Europe, medicine.anatomical_structure, Female, Adiponectin, lcsh:Nutrition. Foods and food supply, Polyunsaturated fatty acid, Human, Adult, medicine.medical_specialty, duration of lactation, Population, hormone, 030209 endocrinology & metabolism, lcsh:TX341-641, Biology, fatty acids, Article, Milk Protein, 03 medical and health sciences, Insulin-Like Growth Factor II, Internal medicine, Fatty Acids, Omega-6, medicine, Humans, education, 030109 nutrition & dietetics, hormones, Milk, Human, Nutrients, Endocrinology, chemistry, carbohydrate, fatty acid, Cohort Studie, carbohydrate, celiac disease, country, duration of lactation, fat, fatty acids, hormones, human milk, celiac disease, Food Science, Hormone, Nutrient |
| الوصف: | Human milk composition is variable. The identification of influencing factors and interdependencies of components may help to understand the physiology of lactation. In this study, we analyzed linear trends in human milk composition over time, the variation across different European countries and the influence of maternal celiac disease. Within a multicenter European study exploring potential prevention of celiac disease in a high-risk population (PreventCD), 569 human milk samples were donated by women from five European countries between 16 and 163 days postpartum. Some 202 mothers provided two samples at different time points. Protein, carbohydrates, fat and fatty acids, insulin, adiponectin, and insulin-like growth factor II (IGF-II) were analyzed. Milk protein and n-6 long chain polyunsaturated fatty acids decreased during the first three months of lactation. Fatty acid composition was significantly influenced by the country of residence. IGF-II and adiponectin concentrations correlated with protein content (r = 0.24 and r = 0.35), and IGF-II also correlated with fat content (r = 0.36), suggesting a possible regulatory role of IGF in milk macronutrient synthesis. Regarding the impact of celiac disease, only the level in palmitic acid was influenced by this disease, suggesting that breastfeeding by celiac disease mothers should not be discouraged. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1714230ce8a5fa2dc91d287688c9663 http://hdl.handle.net/11588/890252 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f1714230ce8a5fa2dc91d287688c9663 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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