The untold stories of the speech gene, the FOXP2 cancer gene
| العنوان: | The untold stories of the speech gene, the FOXP2 cancer gene |
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| المؤلفون: | Maria Jesus Herrero, Yorick Gitton |
| المساهمون: | Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Center for Neuroscience Research, Children’s National Medical Center, NW, Washington, DC, USA (CNR) |
| المصدر: | Genes & Cancer Genes and Cancer Genes and Cancer, SAGE Publications, 2018, 1 (2), pp.11-38. ⟨10.18632/genesandcancer.169⟩ |
| بيانات النشر: | Impact Journals, LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Cell type, [SDV]Life Sciences [q-bio], Review, medicine.disease_cause, 03 medical and health sciences, Breast cancer, oncogene, Genetics, medicine, cancer, Transcription factor, language, Oncogene, business.industry, Cancer, FOXP2, medicine.disease, 3. Good health, 030104 developmental biology, FOXP2 factor, Cancer research, prognosis, business, Carcinogenesis, Monoclonal gammopathy of undetermined significance |
| الوصف: | International audience; FOXP2 encodes a transcription factor involved in speech and language acquisition.Growing evidence now suggests that dysregulated FOXP2 activity may also beinstrumental in human oncogenesis, along the lines of other cardinaldevelopmental transcription factors such as DLX5 and DLX6 [1-4]. Several FOXPfamilymembers are directly involved during cancer initiation, maintenance andprogression in the adult [5-8]. This may comprise either a pro-oncogenic activityor a deficient tumor-suppressor role, depending upon cell types and associatedsignaling pathways. While FOXP2 is expressed in numerous cell types, itsexpression has been found to be down-regulated in breast cancer [9],hepatocellular carcinoma [8] and gastric cancer biopsies [10]. Conversely,overexpressed FOXP2 has been reported in multiple myelomas, MGUS (MonoclonalGammopathy of Undetermined Significance), several subtypes of lymphomas [5,11],as well as in neuroblastomas [12] and ERG fusion-negative prostate cancers [13]. According to functional evidences reported in breast cancer [9] and survey ofrecent transcriptomic and proteomic analyses of different tumor biopsies, wepostulate that FOXP2 dysregulation may play a main role throughout cancerinitiation and progression. In some cancer conditions, FOXP2 levels are nowconsidered as a critical diagnostic marker of neoplastic cells, and in manysituations, they even bear strong prognostic value [5]. Whether FOXP2 may furtherbecome a therapeutic target is an actively explored lead. Knowledge reviewed heremay help improve our understanding of FOXP2 roles during oncogenesis and provide cues for diagnostic, prognostic and therapeutic analyses. |
| تدمد: | 1947-6027 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f172b0fda089b65b447c95e80921382c https://doi.org/10.18632/genesandcancer.169 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f172b0fda089b65b447c95e80921382c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19476027 |
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