Real-Life Management of Children and Adolescents with Chronic Myeloid Leukemia: The Italian Experience
| العنوان: | Real-Life Management of Children and Adolescents with Chronic Myeloid Leukemia: The Italian Experience |
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| المؤلفون: | Franco Locatelli, Fiorina Giona, Maria Caterina Putti, Rosamaria Mura, Andrea Biondi, Concetta Micalizzi, Caterina Consarino, Nadia Vacca, Nicola Santoro, Grazia Iaria, Maria Luisa Moleti, Ottavio Ziino, Giuseppe Menna, Antonella Sau, Fara Petruzziello, Robin Foà, Roberta Burnelli, Saverio Ladogana, Michelina Santopietro, Sayla Bernasconi |
| المساهمون: | Giona, F, Santopietro, M, Menna, G, Putti, M, Micalizzi, C, Santoro, N, Ziino, O, Mura, R, Ladogana, S, Iaria, G, Sau, A, Burnelli, R, Vacca, N, Bernasconi, S, Consarino, C, Petruzziello, F, Moleti, M, Biondi, A, Locatelli, F, Foà, R |
| المصدر: | Acta Haematologica. 140:105-111 |
| بيانات النشر: | S. Karger AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Childhood leukemia, Chronic myeloid leukemia, Imatinib, Tyrosine kinases, Hematology, Pediatrics, medicine.medical_specialty, Adolescent, Referral, 03 medical and health sciences, 0302 clinical medicine, Bone Marrow, HLA Antigens, medicine, Humans, Child, Tyrosine kinase, Protein Kinase Inhibitors, Life management, business.industry, Hematopoietic Stem Cell Transplantation, Myeloid leukemia, General Medicine, medicine.disease, Transplantation, medicine.anatomical_structure, Imatinib mesylate, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Italy, Child, Preschool, 030220 oncology & carcinogenesis, Leukemia, Myeloid, Chronic-Phase, Imatinib Mesylate, Female, Bone marrow, business, 030215 immunology, medicine.drug |
| الوصف: | Background: To date, no data on the adherence to specific guidelines for children with chronic myeloid leukemia (CML) in chronic phase (CP) have been reported. Methods: Since 2001, guidelines for treatment with imatinib mesylate (IM) and monitoring in patients younger than 18 years with CP-CML have been shared with 9 pediatric referral centers (P centers) and 4 reference centers for adults and children/adolescents (AP centers) in Italy. In this study, the adherence to these guidelines was analyzed. Results: Thirty-four patients with a median age of 11.4 years and 23 patients with a median age of 11.0 years were managed at 9 P and at 4 AP centers, respectively. Evaluations of bone marrow (BM) and/or peripheral blood (PB) were available for more than 90% of evaluable patients. Cytogenetics and molecular monitoring of PB were more consistently performed in AP centers, whereas molecular analysis of BM was carried out more frequently in P centers. Before 2009, some patients who responded to IM underwent a transplantation, contrary to the guidelines’ recommendations. Conclusions: Our experience shows that having specific guidelines is an important tool for an optimal management of childhood CP-CML, together with exchange of knowledge and proactive discussions within the network. |
| وصف الملف: | STAMPA |
| تدمد: | 1421-9662 0001-5792 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18ebc5f40a9293facfaf58ed6a4c7ed https://doi.org/10.1159/000491546 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f18ebc5f40a9293facfaf58ed6a4c7ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219662 00015792 |
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