LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats

التفاصيل البيبلوغرافية
العنوان: LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats
المؤلفون: Muhammed Yayla, Ilknur Calik, Elif Cadirci, Abdulmecit Albayrak, Muhammet Calik, Busra Sirin, Irfan Cinar, Zekai Halici
المصدر: Inflammopharmacology. 28:893-902
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, Allergy, Nitric Oxide Synthase Type III, medicine.drug_class, Indomethacin, Immunology, Gene Expression, Pharmacology, Piperazines, 03 medical and health sciences, 0302 clinical medicine, Phenols, Enos, Gene expression, medicine, Animals, Pharmacology (medical), RNA, Messenger, Stomach Ulcer, Rats, Wistar, Receptor, Sulfonamides, biology, Chemistry, Stomach, Antagonist, Famotidine, biology.organism_classification, medicine.disease, Amides, Rats, Serotonin Receptor Agonists, 030104 developmental biology, medicine.anatomical_structure, Receptors, Serotonin, Serotonin Antagonists, 030217 neurology & neurosurgery, medicine.drug
الوصف: This study aimed to demonstrate the role of serotonin 7 receptor (5-HT7) and the effects of 5-HT7 agonists and antagonists in an indomethacin-induced gastric ulcer. Male albino Wistar rats (n = 60) were used in the experiments. LP44 (5-HT7 agonist) and SB269970 (5-HT7 antagonist) were administered at 10 mg/kg as a pre-treatment. One hour after the drug treatments, 25 mg/kg of indomethacin (INDO) was administered to all groups except the healthy control group. Six hours after indomethacin administration, all the rats were euthanized. We analyzed the iNOS, eNOS, and 5-HT7 receptor mRNA levels in the stomach tissue of rats by real-time PCR. 5-HT7 mRNA expression was increased in the INDO group compared to the healthy group. LP44 administration exerted a significant upregulatory effect on eNOS mRNA expression and downregulatory effects on iNOS and 5-HT7 mRNA expression compared to the INDO group. However, antagonist (SB269970) administration did not result in such difference in gene expression, but even partially decreased the agonist’s effect in combination. Famotidine and agonist exerted similar effects. Histopathological findings supported the beneficial effects of 5-HT7 agonist on gastric tissue. The study suggested that activation of 5-HT7 receptor showed a significant anti-ulcerogenic effect in the indomethacin-induced gastric ulcer model.
تدمد: 1568-5608
0925-4692
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c0091b7bd86ec0bdc8b1bac1922c2c
https://doi.org/10.1007/s10787-020-00725-3
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....f1c0091b7bd86ec0bdc8b1bac1922c2c
قاعدة البيانات: OpenAIRE